Skip Navigation
SBIR/STTR

On Orbit Immuno-Based, Label-Free, White Blood Cell Counting System with MicroElectroMechanical Sensor (MEMS) Technology (OILWBCS-MEMS), Phase II

Completed Technology Project

Project Introduction

On Orbit Immuno-Based, Label-Free, White Blood Cell Counting System with MicroElectroMechanical Sensor (MEMS) Technology (OILWBCS-MEMS), Phase II
Aurora Flight Sciences Corporation and partner, Draper Laboratory, propose to develop an on-orbit immuno-based label-free white blood cell counting system using MEMS technology (OILWBCS-MEMS) for human spaceflight experimental and medical monitoring practices. Our proposed system is designed to meet NASA's requirements for a microgravity compatible, miniaturized, light weight peripheral blood cell counting instrument capable of on-orbit cell counting, without high energy lasers, requiring minimal sample volume or exogenous (sheath) fluid, and generating minimal bio-hazardous waste: SBIR topic X14.02 "On Orbit Cell Counting and Analysis Capability". The proposed detection technology leverages changes in optical transmission through a surface due to molecular binding (e.g., antibody-antigen binding). Antibodies specific to the white blood cell surface protein markers (antigens) are pre-coated on the sensor surface to recognize specific white blood cell types with inherently high specificity and sensitivity. In Phase I we developed surface chemistry and demonstrated surface chemistry sensitivity and specificity for total white blood cells and two lymphocyte subtypes (B-cells, CD4+ T-cells). During phase II we will develop a functional prototype of the OILWBCS-MEMS device to demonstrate that end-to-end operations from sample-in to signal-out produces clinically relevant results. The OILWBCS-MEMS design will include single-use replaceable cartridges for fluid loop and sensor components. More »

Primary U.S. Work Locations and Key Partners

Project Library

Share this Project

Organizational Responsibility

Project Management

Project Duration

This is a historic project that was completed before the creation of TechPort on October 1, 2012. Available data has been included. This record may contain less data than currently active projects.

A final report document may be available for this project. If you would like to request it, please contact us.

^