A comprehensive model-based approach will be enabled for space systems design via the work started on Phase I of this project. The OpenMETA toolkit is a cyber-physical modeling tool for the design and virtual integration of complex systems, developed under the DARPA AVM Program. OpenMETA will be leveraged and extended to support NASA/JPL goals for multi-physics, multi-domain modeling, analysis, optimization, and uncertainty quantification of spacecraft and space systems. Specific extensions include supporting preferred CAD tool (Siemens NX), FEA Meshing (FEMAP), and IMUQ uncertainty quantification. In addition, the use of external, configuration-managed databases will be supported to track design parameter evolution. The tool's utility will be evaluated and demonstrated via a set of use cases and end-to-end experiments.