Ionu Biosystems will develop a fluorescent smart phone blood analyzer that can measure important physiological concentrations from a drop of blood. The approach will be to develop fluorescent optode sensors to detect the concentration of the components of basic metabolic and blood gas panels. Using wireless optode sensors, which can reduced in size to the nanoscale, and fluorescence signal detection removes the need for wired connection of the sensors, sample preprocessing and microfluidics for sample handling. These advantages will reduce the size, weight and cost of the sample cartridge. Fluorescence emission from the sensors will be directly measured by the built-in phone camera and data processing can occur on the phone itself. The results from Phase I will include the construction of a prototype phone case to provide the necessary optical components to convert a smart phone into fluorescence sensor and response of sensors for the components of a chem8 to different target concentrations measured with the phone prototype. Phase I of this project will satisfy the solicitation requirements.