NASA's current research efforts in aircraft design focus on noise/boom reduction and improvements in fuel efficiency of the next generation sub/supersonic commercial aircraft. These design drivers call for investigation of unconventional and revolutionary design concepts for which the empirical structural and aerodynamic equations based on historical database are not valid. ZONA's innovative modular MDO sub-framework, once incorporated in the NASA MDAO systems, can provide variable-fidelity and physics-based structural, aerodynamic, and aeroelastic solutions, along with the solutions for other disciplines computed by the existing analysis codes available in the NASA MDAO systems, for solving a complete configuration design and optimization problem. With acceleration of convergence achieved through the POD-based order reduction and design space evolution technique, accurate shape sensitivity information provided by incorporation of ZEUS-DO and ZAERO-DO, automated rapid mesh-morphing by Because of the automated mesh generation +morphing capability, unified shape design variable definition for both structural and aerodynamic models, accelerated convergence through order reduction and design space evolution technique, and the streamlined ModelCenter-integrated process for the variable-fidelity structural, aerodynamic and aeroelastic solution generations, ZONA has discovered that the proposed MDAO suite has a unique commercial competitive edge in the air vehicle MDAO software market. Once Zona's highly modular MDAO suite is integrated into an existing MDAO system, it can be adopted by the conceptual design and configuration development departments of airplane manufacturers nationwide and worldwide to develop a wide class of air vehicles such as UAVs/UCAVs, supersonic business jets and transports, advanced transonic transports, fighter aircraft, hypersonic missiles, and winged projectiles.