To address NASA's need for a method to preserve human biological samples, mostly blood and urine, from astronauts collected during flight under ambient conditions, ChromoLogic (CL) has developed a novel Fluid Preservation System (FPS). FPS is based on collecting and sealing fluids in a sterile, hermetically sealed volume, with automatic separation of supernatant fluid where necessary. The unique microfluidic and medical expertise of CL scientists has resulted in an innovative and lightweight fluid storage system that utilizes compact and rugged microfluidic chips and novel valve technology that are capable of processing ~10ml of samples in a few minutes using on-board processing equipment. In Phase I CL has demonstrated the feasibility of the FPS technology by building prototype chips and demonstrating the proof of concept of pumping, separation, storage and preservation. The FPS has been demonstrated to be able to store blood plasma at room temperature for 54+ days. In Phase II CL will develop a fully functional system that will be FDA approved and space qualified.