The proposed single-chip multi-analyte sensors are ideally suited for environmental monitoring and fire protection for space craft autonomy (E-nose, lick and stick integrated monitor), in-flight monitoring system of the trace chemical constituents, which is essential for crew health, safety, and systems operation as well as cell-all program to enhance the performance of the system using a large array of sensors. These sensors are low-power, rugged, and radiation-hard, making them ideally suited for integrated spacecraft monitoring networks. Such ultra-small chemical sensors can be used for mobile devices based multianalyte detectors for industrial monitoring of trace gases (CO2, NH3, etc.), and also for smartphone based environmental pollution exposure monitors for asthma patients. They can be integrated with on-demand ventilation control systems for measuring indoor air quality in buildings.