The Individualized Stress Detection System can be adapted to meet an articulated need to track chronic stress and hyperarousal in occupations associated with high workload and high danger factor such as military operations and law enforcement. A tool that enables the systematic and efficient tracking of sympathetic activation in these occupational settings can provide a means to detect and address stress-related behavioral disorders and mental conditions at an early stage. Taking military operations as an example, there is evidence that stress-related behavioral disorders and mental conditions such as anxiety, depression and post-traumatic stress disorder have a high prevalence among soldiers. There is a present market opportunity to deliver an Individualized Stress Detection System to track changes in objectively-measured, chronic stress levels in soldiers during training, deployment, and post-deployment. The Individualized Stress Detection System will meet the specific requirements of long duration exploration missions and provide feedback to astronauts, Op Psy Personnel and Flight Surgeons about stress levels and hyperarousal as well as aid in the selection of countermeasures. It will be designed to be unobtrusive and to require minimal training and crew effort to utilize. The resulting product will be primarily relevant to NASA's Behavioral Health and Performance (BHP) research gap BMED 3 (What are the optimal methods to detect and assess decrements in behavioral health during exploration missions?) but will also be relevant to gaps BMED1, BMED2, BMED6, BMED7, and BMED8. When validated, the Individualized Stress Detection System will be deployed on ISS to support crew behavioral health during training, mission and return to Earth.