Intelligent Automation Inc. (IAI) proposes an innovative Security-Enhanced Autonomous Network Management (SEANM) scheme for reliable communication in space networking. The SEANM scheme allows the system to adaptively reconfigure its network elements based upon awareness of network conditions, policies, and mission requirements. Existing network management tools in space networking are generally focused on specific missions and/or domains and hence do not provide an integrated and consistent solution for the future NASA space networks. Moreover, to reduce operation costs, autonomous network management is necessary. However, the related research and implementations are still at early stage and demands further investigation. In addition, due to the inherent characteristics of space networks, security aspects that are valid in the traditional networks are not fully suitable to space networks. A novel network management solution with advanced scalability and security is necessary for heterogeneous space networks. The objective of the proposed SEANM scheme is to develop an autonomous network management system so as to provide reliable and efficient support for the science and exploration mission in the future NASA space networks.