The proposed technology will utilize onboard technologies (e.g., high quality video cameras, infra-red sensors) to passively monitor NASA crews while they are on exploration mission beyond low earth orbit. This technology will not only monitor vital physiological parameters, but also will provide risk mitigation strategies and required medical interventions. This will especially helpful in situations when there is not be any real-time communication with the ground control, and emergency evacuation is not feasible. The proposed technology can also be used in the International Space Station to monitor crew health, and make them aware of any abnormal pattern, as well as, provide risk-mitigation strategies. This will help ISS crews to stay in good health during their mission. The passive vital signs monitoring technology to be developed in this project will play a crucial role in healthcare industry. US health care system is struggling with aging population, prevalence of chronic diseases, and accompanying rising cost. It is envisioned that future healthcare system should be preventive, predictive, preemptive, personalized, and pervasive. The proposed algorithm will be capable of processing physiological information collected from other sensor systems (e.g., wearable), and make prognosis and diagnosis, as well as, provide plans for risk mitigation and medical intervention. Therefore, it can easily be a part of healthcare solution for home, sanatoriums, as well as, hospitals. In addition, the proposed technology will be beneficial for those who leave in low-resource settings, where access to healthcare facility is not easy.