In recent findings, we showed that dried plum (DP) diet conferred complete protection from the rapid bone loss induced by exposure to radiations, including gamma, protons, and High Z-High Energy (HZE) ions. Based on these very promising results on a new potential countermeasure for space radiation tissue damage, we propose to conduct additional studies and analyses, which are critical for moving the potential countermeasure to a higher countermeasure readiness level (CRL) level. We aim to test the DP diet to prevent bone loss induced by simulated spaceflight. This will be achieved by exposing mice to each factor (weightlessness and radiation) alone and combined. Furthermore, we will establish if DP protects other tissues at risk for astronauts, such as the central nervous system.