During Phase I, M4 Engineering integrated a prototype system into OpenMDAO, a NASA GRC open-source framework. This prototype system was a proof-of-concept that M4 physics based modules could be integrated in OpenMDAO. The results generated in OpenMDAO compared well to the results generated in another framework, ModelCenter. Phase II will be a demonstration of enhanced system functionality with the integration of additional modules and design tools. The integrated objects will perform discipline-specific analysis across multiple flight regimes at varying levels of fidelity. The process will also deliver system-level, multi-objective optimization. Phase II will also showcase a refined system architecture that allows the system to be less customized to a specific configuration (i.e., system and configuration separation) as well as additional example problems. By delivering a capable and validated MDAO system along with a set of example applications to be used as a template for future users, this work will greatly expand NASA's high-fidelity, physics based MDAO capabilities and enable the design of revolutionary vehicles in a cost effective manner. This proposed work compliments M4 Engineering's expertise in developing modeling and simulation toolsets that solve relevant subsonic, supersonic, and hypersonic demonstration applications.