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Small Business Innovation Research/Small Business Tech Transfer

Nanoscale Test Strips for Multiplexed Blood Analysis, Phase II

Completed Technology Project

Project Introduction

Nanoscale Test Strips for Multiplexed Blood Analysis, Phase II
The goal of our nanoscale test strips, or nanostrips, is to provide rapid, low-cost, powerful multiplexed analyses in a diminutive form so that whole body health checks can be performed on a single drop of blood. The approach is conceptually similar to pH or urinalysis test strips which allow multiplexed measurements in a linear format. The main difference is that we are proposing test strips at the nanoscale, shrunk in size over a billion-fold in volume, allowing multiple sensing elements to be included in a tiny area. In Phase I, we fabricated, tested, and demonstrated functional parathyroid hormone and vitamin D nanostrips for bone metabolism. Furthermore, we developed thrombin aptamer and immune IgG antibody nanostrips. For Phase II, we will develop a breadth of nanostrips designed to address key space-flight medical needs. These will be for assessment of bone metabolism, immune response, cardiac status, liver metabolism, and lipid profiles. We plan to enhance our technology capabilities by developing a Rapid Nanostrip Assay Capability, mix-and-run assay capability, in-house aptamer production, advanced lyophilization technology, and nanostrip accelerated stability tests. The nanostrips will be read out in a time-of-flight flow-based manner utilizing our rHEALTH sensor. More »

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