Today, memory and payload processing systems for space applications are typically designed for a specific application for a specific mission. Many of these systems do not employ a commercial standard which adversely affects the development costs, risks, and schedule while minimizing effective reuse of capabilities. Traditional commercial standards such as PCI are limited in bandwidth and reliability and do not meet the needs of advanced space payloads. New standards, like VPX, do show promise. VPX supports module to module datarates of 10 Gbps. VPX supports multiple switch architecture, so redundancy is supported. With newer large capacity memory components, a high capacity modular architecture is achievable which opens the door for adoption of a commercial standard for space payload and memory systems.