Various critical analog and mixed-signal circuits are used in space electronics, such as, DoD space systems (communication, surveillance, ballistic missiles, missile defense), and commercial satellites. Since modern electronic technologies and parts are getting smaller all the time, the radiation and extreme temperature effects become more severe, the life time and reliability become critical, and the capability to predict them increases confidence and reduces risk. The new RHBD designs and circuit/cell libraries, as well as the physics-based computer aided design (CAD) tools, can also be applied to cryogenic electronics for high-sensitivity, low-noise analog and mixed-signal applications, such as metrology, infrared (IR) imagers, sensors (radiation, optical, X-ray), radiometrology, precision instruments, radio and optical astronomy, infrared and photon detectors, and other high-end equipment. For all such devices and systems, predictive and accurate modeling and design tools reduce the amount of required radiation/temperature testing, thus decreasing their cost, and time to market or field application. Prediction of electrical performance and radiation hardness of electronic components in extreme environments (wide temperatures, high radiation) are crucial to design reliable electronics for all NASA Exploration Missions, for both crewed and robotic systems. Since electronic parts are getting smaller, the radiation/temperature effects are more severe the life time and reliability become critical the physics-based capability to predict them increases confidence and reduces risk. Radiation-hardened and wide-temperature analog and mixed-signal circuits are essential for all the avionic systems used in the NASA Constellation and other exploration projects for which advanced technologies are being developed by the Exploration Technology Development Program (ETDP). The optimized, wide-temperature RHBD designs from this SBIR will add to the pre-existing NASA "component library" being developed in the ETDP SiGe electronics effort. The new tools and RHBD circuits will be immediately applicable to the NASA Radiation Hardened Electronics for Space Exploration (RHESE) Program. The wide-temperature physics-based mixed-mode tools will help NASA to design rad-hard analog and mixed-signal electronics with better understanding and control of design margins; better evaluate the wide-temperature performance and radiation response at an early design stage; set requirements for hardening and testing; and reduce the amount of testing cost and time.