Control and management of cryogenic propellant tank pressures in low gravity is an important technical challenge to overcome for future long duration space missions. Heat leaking into the propellant tanks leads to self-pressurization of the tank due to vaporization. Advanced techniques such as thermodynamic vent systems (TVS) are currently being designed for low-gravity space systems. However, these systems are more complex to analyze and system level tools based on lumped, homogeneous models are inadequate for determining sensitivities to multi-dimensional fluid transport and dispersed multi-phase effects. The innovation proposed here is a comprehensive, CFD framework to support analyses of cryogenic tank management systems that will incorporate both real-fluid equations of state for cryogenic fluid mixtures with rigorous fluid property definitions, as well as an advanced dispersed phase spray model that permits non-equilibrium drag and heat transfer with the surrounding continuum fluid. The proposed effort will evaluate various sub-models for the vaporization/condensation of the cryogenic fluid droplets in an environment that includes a mixture of vapor and non-condensable gas. This technology will impact cryogenic systems for long duration space exploration activities.