Due to the extensive amounts of data generated from the genome sequencing projects, the focus of genomics has shifted from elucidating DNA sequence to the interpretation of gene function. In addition, as proteins are most often the targets of drugs, a method of studying the genome at the protein level is fueling the pharmaceutical industry?s interest in proteomics. By interpreting the interacting partners of a protein of interest and stimuli that affect these conditions, much can be learned about the protein?s function. To help fuel the proteomics revolution, Agave BioSystems, in collaboration with Dr. Robert Boyd, of the Institute of Optics at the University of Rochester, proposes to develop an ultra sensitive analytical tool based on whispering gallery mode (WGM) resonator technology for the detection of protein-protein interactions. Simulations have demonstrated that WGM resonator technology can provide several orders of magnitude greater sensitivity as compared to current detection mechanisms such as SPR. The microfabrication of this detection mechanism, coupled with microfluidic systems to be developed in the Phase II, will result in a disposable biochip that can be readily used in a small, compact and portable instrument.