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Human Research Program

Preventing Secondary Brain Injury by Early Detection of Cerebral Bleeding and Edema

Completed Technology Project

Project Introduction

Preventing Secondary Brain Injury by Early Detection of Cerebral Bleeding and Edema

The goal of this project was to 1) improve the Cerebrotech Intracranial Fluid Monitor clinical prototype device design and 2) establish human feasibility through clinical trials. Both objectives have been achieved. The prototype was improved by 1) redesigning the mechanical patient interface, 2) improving the electronics to maximize signal-to-noise ratio, and 3) developing algorithms to correlate the intracranial fluid volume (ICF) measurements to intracranial pressure (ICP) measurements on patients in the ICU with severe brain injuries. The study results demonstrate that ICF measurements correlate linearly with ICP in patients exhibiting good intracranial compliance. And, conversely, patients with poor intracranial compliance display a poor correlation of ICF to ICP. These results confirm our original hypothesis based on established neuroscience, and demonstrate the feasibility of non-invasive ICF monitoring using VIPS technology. We believe our study was the first to demonstrate the relationship of intracranial fluid volume and pressure using real-time, continuous ICP and ICF measurements in human patients with brain injury. Continued clinical research and validation is warranted.

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