The successful development of the proposed ultra sensitive SERS sensor instrument will have extensive NASA's applications. The proposed system will create an opportunity to extend and enhance the capability of traditional NASA Earth and Planetary detection efforts in current platforms. It meets NASA's multiple-mission requirements for the best use of limited resources by reducing the risk, cost, size, weight as well as power consumption. It will also enable new measurements with greatly enhanced sensitivity for the planetary study. This technology will be useful for a broad range of in situ measurements for: space science and terrestrial geochemical, geophysical and geobiological studies; planetary protection applications. Ultra sensitive spectral sensors have wide applications to include homeland security, life science, and matter physics and chemistry. It offers a fast, sensitive and accurate method of analysis suitable for both laboratory-based and plant based applications. In addition, a broad range of non-government commercial and industrial applications include environmental testing of water, soil and air; municipal and industrial water and waste-water quality testing; commercial product quality control testing of manufactured food, chemical, semiconductor, and other commercial products. Furthermore, laser spectral sensors have potential to provide the unique sensitive fluorescence-free and real-time analysis for biofuel production and oil exploration in energy industry.