Civilian pre-hospital providers (e.g., paramedics and emergency medical technicians) collect and act upon a wide variety of complex visual clues, while monitoring and adjusting to continually changing sets of vital signs. Pre-hospital vital sign information in the form of trending data is rarely integrated into the patient care record, so how the vital signs change in response to specific treatment measures is largely undocumented and poorly understood. As a consequence, the care that is provided to a patient in the field is anticipatory and reactive. It is not time sensitive and the accompanying patient medical record is oftentimes incomplete. Healthcare providers do not give medications or adjust the ventilator and IV fluids as often or as accurately as a smart, vigilant system might and, as a result, patients likely do not respond or recover as quickly as they could. We have developed a fully integrated system for mobile critical care patient support and documentation. The iRevive-LTM system is composed of physiological sensors, monitors, and therapeutic hardware devices, linked by a suite of software applications. The components integral to the LTM include: a ventilator; 3/5/12-lead ECG (electrocardiogram); pulse oximeter; noninvasive blood pressure (NIBP); end-tidal carbon dioxide (EtCO2); patient temperature; invasive arterial and intracranial pressure monitoring capabilities; Ethernet communications; closed-loop control of oxygenation (and soon ventilation and IV fluid control); an integrated electronic medical record (iRevive) for clinical data storage and export; alarming, and smart help. The LTM supports up to three external intravenous (IV) pumps and is designed to support other to be developed noninvasive monitors, all connected via powered-USB ports. It supports several additional modules, including an oxygen concentrator, patient warming, and an anesthesia control module. Software will oversee a growing number of autonomous care applications within the integrated system, which will reduce the need for constant attention by a healthcare provider or crew medical officer. While space flight design requirements are of paramount importance to the current project, we are cognizant of U.S. military funding and civilian needs for improved transport monitoring technology. The small, lightweight, rugged, low power design specifications for space flight are equally important here on Earth. A transport monitor that goes into space should have facility for remote calibration and maintenance, as should a transport monitor that is deployed on the battlefield or in other remote locations. Incorporation of redundant systems, automated alarms and, increasingly, closed loop control algorithms will be essential. The value of consolidating patient monitoring, support, and documentation into a single system, capable of automatically collecting and transmitting real-time patient care data, cannot be overemphasized. Integrating these data streams has many advantages, not only in providing real-time information display both locally and centrally for triage decision support, but in trauma system development. More importantly, the physiologic and electronic patient care data that will be captured by the iRevive-LTM system will be fully integrated and time synchronized. New state-of-the-art machine learning, feature extraction, and advanced statistical methods are showing great promise in analyzing these types of complex data sets, uncovering many important, previously hidden physiological relationships and treatment effects. As these relationships are further defined and understood, our models of health and disease will become more complex and accurate. They will provide more reliable, real-time insight into the current and predicted future status of our patients. In time, machine-based comprehension of semantic clinical information together with real-time physiological data will lead to the development of fully autonomous patient care systems.