The knowledge gained from this research, though focused on space flight, also may benefit people on Earth. The circadian disruption experienced by astronauts during space flight can be considered a threat to the success of space missions (Longnecker and Molins, 2005; NASA Human Research Program Integrated Risk Plan, 2011). The resulting physiological and behavioral changes caused by circadian and sleep disruption can lead to diminished alertness, cognitive ability, and psychomotor performance (Dijk et al., 2001). Over 45% of all medications taken in space are sleep aids taken as a measure to counteract sleep deficits (Putcha et al., 1999). Although the studies in this project are focused on developing a non-pharmacological lighting countermeasure for space exploration, it is anticipated that there will be benefits to civilians. A significant portion of the global population suffers from chronic sleep loss and/or circadian-related disorders. Evidence for disease or illness due to a circadian disruption has mounted significantly. Nearly 22 million Americans do shift work that interferes with a biologically healthy nocturnal sleep cycle (U.S. Bureau of Labor Statistics, 2007). Shift workers have been shown to be more likely to suffer from a wide variety of ailments, including cardiovascular disease, gastrointestinal distress, and cognitive problems. Furthermore, epidemiological studies of female shift workers have shown that they are more likely to suffer from breast cancer and colon cancer compared to day shift workers. The World Health Organization has identified shift work as a probable risk for cancer (The International Agency for Research on Cancer, 2007). This past year the American Medical Association acknowledged the harmful effects of widespread electrical lighting at night (Council on Science and Public Health Report Report, 2012). Our laboratory is involved in testing the hypothesis that night time exposure to light suppresses melatonin and contributes to cancer risk (Blask et al., 2005; Mao et al., 2012). Aside from evidence of a breakdown in physical health, the effects of circadian disruption and sleep loss have long been known to have potentially dangerous behavioral effects. Mental fatigue, diminished alertness, loss of psychomotor coordination, and decreased physical performance are all commonly found in individuals with sleep loss, sleep debt, or circadian misalignment. Many people also experience the same effects after air travel across several time zones. The impact of these deficits affects many industries, including transportation, manufacturing, communications, medicine, and homeland security. It has long been a source of concern for the military, as well. In the past, the U.S. Air Force has supported our laboratory to study the acute alerting effects of light (French et al., 1990; Brainard et al., 1996). Our past work for NIH (National Institute of Health) has continued this effort (Lockley et al., 2006). Existing therapeutic lighting interventions stand to benefit from enhancing our understanding of how different wavelengths of the spectrum affect human circadian and neurobehavioral regulation (Byrne and Brainard, 2012). A more efficient intervention with increased potency and/or fewer side effects could result. One such disorder currently being treated with bright white light is Seasonal Affective Disorder (SAD). It is estimated that as many as 1 in 5 Americans suffer from SAD or its milder version, sSAD (Lam and Levitt, 1999). Similar bright white light interventions also are used to treat jetlag. Side effects from exposure to bright white light for these and other therapies include: hypomania, headache, vision problems, nausea, dizziness, and anxiety. Optimizing the light spectrum for specific affective and/or circadian-related disorders could deliver the same medical impact with lower levels of light intensity and, potentially, with fewer side effects. Our group has completed Phase I testing of light therapy with blue solid-state lighting for patients with SAD (Glickman et al., 2006).