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Human Research Program

An Integrated Musculoskeletal Countermeasure Battery for Long-Duration Lunar Missions

Completed Technology Project

Project Description

An Integrated Musculoskeletal Countermeasure Battery for Long-Duration Lunar Missions
In the past year, we carried out a study to evaluate the effects of ab/adduction exercise on spine bone density and hip bone strength and density measured by quantitative computed tomography and finite element modeling. In 24 healthy subjects, we compared standard aRED lower body exercise, combined aRED, and ab/adduction and ab/adduction only, maintaining the same number of repetitions per group, in a 16 week study, with three exercise sessions per week. Eight subjects were assigned to each group. At the end of the study, two subjects had dropped out, leaving us with 8 subjects in the Ab/Add group, and 7 subjects each in the aRED and combined groups. The three groups showed differential responses of spine and hip bone density and hip bone strength to 16 weeks of training. The group of subjects doing aRED-like exercise consisting of squats and deadlifts showed robust increases in vertebral trabecular bone density (9% p<0.05), as well as smaller but statistically significant increases in femoral neck integral bone density, femoral neck cortical bone density, and femoral neck cortical volume. No changes were observed in the trochanteric region of the hip. No changes were observed in trabecular bone at any subregion of the hip. Using non-linear finite element modeling based on the quantitative computed tomography (QCT) images, we estimated changes of hip whole bone strength under simulated conditions of single-legged stance and a posterolateral fall. We observed that in the aRED-like group, there was a 9% increase in stance strength (p<0.05) but not in fall strength. The group of subjects carrying out abduction and adduction exercise showed no changes in any of the vertebral bone parameters. Abduction and adduction exercise resulted in changes in cortical bone parameters at the trochanter, with a 4.4% increase (p<0.01) in cortical bone volume, and a marginally insignificant 2.1% increase in the trochanteric compressive strength index, which integrates bone density and size to provide a measure of the resistance of the trochanter to compressive loading forces. Finite element computed strength in simulated fall loading resulted in a borderline insignificant trend (p=0.15) towards an increase (5.5%). The group doing combined exercise (half aRED-like and half abduction and adduction) showed no changes in any of the bone parameters. Thus, our study showed that standard aRED exercises consisting of squats, deadlifts, and heel raises have an osteogenic effect on the spine and to a lesser extent on the hip, focused on the femoral neck. While abductor and adductor exercise appears to have a modest osteogenic effect (cortical bone formation) on the trochanter of the hip, the failure of the combined group to show any changes indicates that any adbuctor/adductor exercise needs to be carried out in addition to the standard exercise protocol. The modest effects hint that the proper focus of the exercise could be functional mobility and strength rather than bone protection. More »

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This is a historic project that was completed before the creation of TechPort on October 1, 2012. Available data has been included. This record may contain less data than currently active projects.