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Human Research Program

Efficacy of Jobst Compression Garments to Prevent Orthostatic Intolerance for up to Three Days following 14 Days of Bed Rest

Completed Technology Project

Project Introduction

Aims: 1. To determine whether subjects wearing breast-high, graded compression garments become orthostatically intolerant after 14 days of head-down tilt bed rest (Groups 1 and 2). Measures of efficacy will be presyncope-free survival to 80° head-up tilt testing and responses in blood pressure, heart rate, stroke volume, and cardiac output. 2. To determine the time course of cardiovascular readaptation during the first three days of post-bed rest (BR) recovery after using compression garments for a short period of time on BR+0 (Group 1). The brief usage of high compression garments on BR+0 models the use of the anti-G suit (AGS) among Space Shuttle crewmembers. Readaptation will be measured by responses of blood pressure, heart rate, stroke volume, cardiac output, and presyncope-free survival time to 15-minute head-up tilt tests on BR+1 and BR+3 as well as measures of plasma volume each day of recovery. 3. To determine the effect of wearing graded compression garments on the time course of cardiovascular readaptation during the first three days of post-bed rest recovery (Group 2). Readaptation will be measured by responses of blood pressure, heart rate, stroke volume, cardiac output, and presyncope-free survival time to 15-minute head-up tilt tests on BR+1 and BR+3 as well as measures of plasma volume each day of recovery. More »

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