The proposed pilot study provides an opportunity to test the feasibility of a protocol to use with astronauts and other NASA personnel (e.g., flight surgeons, flight directors, and flight controllers) to assess potential carry over effects from sleep medications used during spaceflight operations (including overseas training periods), and following an abrupt awakening from sleep. This information is critically needed to establish optimal and individually tailored usage of sleep medications by key personnel relative to operational demands. The proposed protocol is a feasibility study that will determine the percentage change in sleep inertia from using a medication compared to normal sleep inertia. Subject participants will each choose a hypnotic as their preferred sleep aid; once an appropriate medication is identified, each subject volunteer, in a controlled setting in the Crew Quarters Facility at Johnson Space Center (JSC), will undergo several awakenings during two nights of sleep (one night with the medication, another night with a placebo). Cognitive performance, using a set of three measures, will be evaluated at each awakening. This process will occur under the direction of the study Principal Investigator, a NASA Flight Surgeon.More »
This information is critically needed to establish optimal and individually tailored usage of sleep medications by key personnel relative to operational demands.
|Organizations Performing Work||Role||Type||Location|
|Johnson Space Center (JSC)||Lead Organization||NASA Center||Houston, Texas|
|Harvard Medical School||Supporting Organization||Academia||Boston, Massachusetts|
|University of Maryland, School of Medicine||Supporting Organization||Academia||Maryland|
The study protocol was successfully pilot tested with N=7 subjects (6 NASA flight surgeons and 1 Behavioral Health and Performance element Operations professional) as subjects from March through June, 2009. The pilot study results supported the scientific feasibility of conducting a randomized, double-blind, placebo controlled study of sleep medication effects on alarm-based awakenings. Preliminary analysis from the pilot study indicated differences in performance upon abrupt awakening between the sleep medication and placebo conditions. Thus, the pilot data also support the likelihood of new scientific and clinical insights from the proposed Phase II studies with NASA astronauts.
This is a historic project that was completed before the creation of TechPort on October 1, 2012. Available data has been included. This record may contain less data than currently active projects.