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Human Spaceflight Capabilities

Nutritional Countermeasures to Ameliorate Losses in Muscle Mass and Function

Completed Technology Project

Project Introduction

We have completed this project and have studied the effects of chronically elevated cortisol and hypocaloric diet throughout 14 days of bed rest on muscle protein, lean body mass (LBM), and muscle function. We have completed 13 subjects. Preliminary evidence indicates that combined elevation of cortisol and a hypocaloric diet throughout bed rest increases muscle resistance to the action of insulin and increases the loss of lean body mass. This investigation is relevant to both clinical and astronaut populations, as both are prone to under-nutrition during a stress state. Further, we intend to investigate nutritional and exercise countermeasures with this model to determine an optimal operational countermeasure that can be economically (in terms of crew time and payload) utilized to ameliorate muscle loss during prolonged space flight. More »

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This is a historic project that was completed before the creation of TechPort on October 1, 2012. Available data has been included. This record may contain less data than currently active projects.