The proposed load-bearing, tank-applied, multi-layer insulation system consists of a set of highly reflective radiation shields made from 1 mil thick aluminized Mylar that is supported from a "pop-up tent like" support frame. In addition, the support frame carries the mass of an actively cooled shield and outer MLI blanket enabling ultra low heat leak storage of cryogenic fluids. The support frame is conveniently mounted to the top and bottom center tank penetrations, eliminating any direct supports to the cryogen tank itself, which reduces the heat leak to near the theoretical minimum. The novel design approach is significantly better than conventional MLI, which does not possess the required structural or thermal capabilities required. The technical approach is to integrate low-risk, high Technology Readiness Level (TRL) (TRL 7-9) components into a new and unique low-cost, light-weight, high-strength, thermally efficient MLI system. This approach enables the system to meet and exceed all requirements for reduced heat leak, low-mass, and high strength to withstand flight loads. The NASA Cryogenic Propellant Storage and Transfer Program will directly benefit from the development of the proposed MLI system.