Mission-aware payloads offer the potential for autonomous platforms to achieve unprecedented levels of accuracy and information density in the sensing products they acquire, package, and deliver to remote operators around the globe. Sentix' successful development of a "smart payload" that is mission and platform aware relative to an operating environment will enable NASA to apply this technology to long-duration earth science missions collecting imagery (EO/IR/HS) across a variety of terrains and atmospheric conditions. It is important to note that integration of sensing intelligence into payload systems will yield implications well beyond terrestrial / earth-bound applications. Space robotics used for exploration of other worlds will present the same, if not significantly greater, challenges with regards to C2 and data links. Because the optimal sensing capabilities can be realized in both airborne and surface environments, robotic platforms in both domains will benefit, yielding rovers, winged fliers, and rotor / flapping flight explorers that can operate with substantially greater autonomy than is currently available to NASA. The new capabilities and embedded technology to emerge from this STTR effort will be directly applicable to nearly all inventory platforms (e.g., Predator, Reaper, Shadow) with the possible exception of the lightest weight systems such as Raven and Wasp. Placing the 'smarts' forward into the aircraft and sensor itself will literally embody sensor intelligence onto the battlefield and help to empower autonomy machines, allowing commanders to decide whether they can, at this point in the future, be granted agency to act on behalf of the commanding nation. Beyond DoD applications, DHS-CBP will find widespread use for self-optimizing sensor platforms to aid in border coverage and port overwatch. Similarly, FEMA's ability to use optimal sensing capabilities during response to disasters, e.g., hurricanes, floods, tornados, and management of ongoing recoveries will yield positive results.