The primary focus of Integrated Vehicle Health Management (IVHM) has been on faults due to hardware failures. Yet software is growing in complexity, controls critical functionality under a wide range of conditions and does so with greater autonomy. Furthermore, software errors have negatively impacted major missions. Runtime recovery from software faults is gaining momentum in research community with major efforts such as the IBM autonomic computing effort and the Stanford/Berkeley Recovery-Oriented Computing project. We propose application of these methods to flight software in the context of JPL's Mission Data System (MDS), an integrated systems and software architecture for next-generation space missions. Specifically, we consider: ? Detection and repair of radiation induced Single Event Upsets (SEU) that can either change data values or code. ? Recovery from bugs manifested as the use of computational resources outside of a specified mode-dependent resource profile. ? Software organization and infrastructure to help diagnose and limit the impact of errors. We shall study how to restructure MDS as a distributed system with redundant hierarchical components. ? A recovery strategy based on component-level rebooting. This STTR is a cooperative project between the small business Kestrel Technology and NASA's Jet Propulsion Laboratory (JPL).