As NASA shifts its focus from low-Earth orbit to deep space missions, the agency is investing in the development of technologies that will allow long-duration mission crews to manufacture the products they need, rather than relying on the current practice of resupply missions from Earth. The CUBES institute will advance research into an integrated, multi-function, multi-organism bio-manufacturing system to produce fuel, materials, pharmaceuticals and food. While the research goals of the CUBES institute are to benefit deep-space planetary exploration, these goals also lend themselves to practical Earth-based applications. For example, the emphasis on using carbon dioxide as the base component for materials manufacturing has relevance to carbon dioxide management on Earth. The CUBES team is led by Adam Arkin, principal investigator at the University of California, Berkeley, in partnership with Utah State University, the University of California, Davis, Stanford University, and industrial partners Autodesk and Physical Sciences, Inc.