Develop a multifunctional biomimetic material that exhibits damage tolerant and self‐healing adhesive properties for space and terrestrial applications that is activated by a simple sugar solution. Biomimicry and biomimetic materials are enabling technologies that support journey to Mars exploration for structural applications In this case, collagen molecules are covalently bonded to a hard inert surface like titanium (Ti), this will allow for adhesion between two Ti structures, similar to how ligaments attach to bones. Self‐assembly of ~100 um long collagen fibrils initiated by the covalently bonded molecules will form a microscopic brush like surface structure. When two such surfaces are brought together, the brushes will interdigitate. Subsequent exposure to a simple sugar solution (i.e. glucose in water) causes covalently crosslinking between the brushes. This new material system would rely on the robust properties of collagen fibrils to create a bio-inspired adhesive that is more resilient than cyanoacrylates, more amenable to in-situ repair, and can bond rough surfaces without the need for toxic or hazardous chemicals or solutions. In addition, the adhesive can be released using an enzyme that functions in water near neutral pH. Eliminating complex permanent adhesives will benefit robotic construction allowing parts to be repositioned if necessary in the event of misalignment. Additionally, in-situ resource utilization (ISRU) can be leveraged to provide the liquid water required for the solution, resulting in a significant reduction in launch mass. This would be accomplished by employing a multi-disciplinary process. In this low TRL proof of concept proposal, we initially create Ti surfaces with collagen fibrils oriented with their axis of symmetry perpendicular to the Ti surface. Two fibril containing surfaces will be placed into contact and the interface saturated with a sugar solution. Mechanical properties of the interface will be evaluated including tensile and shear strength and stiffness. The joined parts will then be separated and rejoined and mechanical properties re-‐evaluated. The goal is to demonstrate the ability to fuse two Ti substrates together via a biomimetic interface (collagen fibrils) and to evaluate robustness of the interface.