Multidimensional Processing and Visual Rendering of Complex 3D Biomedical Images, Year 3

The proposed technology uses advanced image analysis techniques to maximize the resolution and utility of medical imaging methods being used during spaceflight. We have applied advanced data reduction and multidimensional imaging techniques, utilized in analysis of Planetary Sciences and Cell Biology imaging, to significantly increase the information that can be extracted from the onboard biomedical imaging systems. In years 1&2 of this IR&D, we focused on application of these techniques to ocular imaging using optical coherence tomography (OCT) and have demonstrated the ability to track volume changes in the choroid, optic nerve head (ONH) and retinal substructure in ocular images collected on ground test subjects and ISS crewmembers. This work resulted in a revision of the on orbit OCT protocol and successful completion of two inflight tests before completion of year 2. In year 3, we completed the initial infusion point, bringing these technical benefits to the on orbit OCT testing and follow on clinical assessment of OCT images. In addition, this work has contributed to the approval for OCT upgrades to the ground and flight medical OCT hardware. Finally, the extension of these techniques to non-ocular images at the cellular/subcellular have been applied and are currently being used for structure/function assessment of various cell types