The goal of this project is to incorporate weather forecasts and reported DF and ChikV case data into a disease transmission model to forecast disease case numbers in Caribbean countries. MSFC is a unique location where mature public health and meteorological expertise co-exists, positioning NASA to develop innovative capabilities that can aid public health officials in fighting disease outbreaks. Weather forecasts will drive the model. Prior weekly DV and ChikV case data will be used to re-parameterize the model so that the most up-to-date and relevant information informs the forecasts. Predictions will be evaluated against actual reported DF and ChikV case data. This project will produce a prototype for an innovative disease forecast system for use by public health agencies and officials.