The need for the proposed capabilities is emerging as NASA seeks to provide higher quality fault management systems for its missions. The model-based fault detection and isolation system could support current and future programs with applications on the ground, in support of recovery operations, and in space, providing onboard autonomous fault detection and isolation. The fault management core diagnostic algorithms are general in nature and do not need tailoring to specific programs. User-supplied models allow customization to a particular target. Thus the developed system will be applicable to a very broad range of NASA mission classes from small to large, near-Earth to interplanetary, risk-adverse, and experimental. In particular missions such as Europa and Mars 2020 would greatly benefit from this technology. Ultimately, NASA and industry partner fault management products will enjoy a larger customer base. The potential market includes a wide range of customers from systems engineering, mission planning, and operations groups in all NASA centers especially ARC, JPL, and MSFC. The need for robust and reliable onboard fault management will increase dramatically as spacecraft systems become more autonomous. The DoD's drive to increase situational awareness has already pushed it into exploration of autonomy-enabling architectures, including improved fault detection and isolation techniques, which will only increase as spacecraft autonomy moves into the broader spacecraft industry. The solution consists of diagnostic algorithms that utilize models provided by the users. The system can thereby be targeted for virtually any mission class. The proposed model-based FM solution is particularly well suited for spacecraft with modular HW/SW architectures. These new architectures will require updated approaches to FM and tools to support them. Potential non-NASA customers include: Large, medium and small prime contractors DoD Labs (NRL, AFRL) FFRDCs/UARCs (Aerospace Corporation, JHU/APL) Non-US organizations (ESA, JAXA, CNES, DLR). This technology is particularly suited for modular architectures such as the Space Missile Command's Modular Space Vehicle (MSV).