In practically all air-vehicle MDO studies to date involving configuration shape optimization, dynamic Aeroservoelastic constraints had to be left out. Flutter, gust stresses, vibration, and ride comfort cannot still be accounted for in MDO involving configuration shape variations. Development of the missing MDO building block is proposed here: A design-oriented ZEUS-DO CFD-based unsteady aerodynamic capability with 3D configuration shape sensitivities, integration with commercial structural finite element codes and with aeroelastic / aeroservoelastic stability / response behavior analysis and sensitivity analysis in the time and frequency domains for non-linear and linearized flows. Phase I will focus on shape parametrization and mesh, pressure, and generalized force sensitivities with respect to shape design variables of multi-lifting-surface configurations. Accuracy and numerical efficiency of the new capability will be demonstrated. In Phase II the ZEUS-DO development effort will proceed to complex 3D configurations including fuselages, nacelles, and external stores. Integration with structural Finite Element design-oriented codes and aeroelastic stability / response solvers, together with validation, assessment of numerical efficiency, and commercialization will be pursued. The new ZEUS-DO capability will provide rapid CFD-based unsteady aerodynamic modeling, analysis, sensitivity analysis, and approximation for re-analysis and for optimization with industry standard accuracy and complexity of configurations modeled.