The development of an integral structural-insulation-TPS cryotank can reduce parasitic insulation requirements by early 10,000 lbs for a shuttle tank equivalent for future launch vehicle systems. The addition of validated ICME for closed cell foam-core multilayer structures can speed insertion of multifunctional hot structures for a variety of applications, ranging from hypersonic acreage structures to low boil-off cryotanks and dry bay structures. Integrating structural cryogenic insulation into a sandwich panel construction can be enabling for zero boil-off storage systems for interplanetary missions. Improved cryogenic structures, including structural cryogenic insulation can reduce the cost of commercial space launch services. reducing heat losses in low and high temperature storage and piping systems can result in improved economics and safety for liquified natural gas (both large scale and transportation tanks), and improved geothermal and offshore energy pipelines.