Programs to monitor the health and wellness of NASAs first astronauts drove the early development of technology for monitoring human physiology. The commercial evolution of these early physiologic sensors has since transformed clinical health care in terrestrial operating rooms, emergency departments, and cardiac care units. NASA programs for Human Health, Life Support, and Habitation Systems (HLHS - technology area 06) are likely to benefit from highly leveraged commercial biosensor development and integration. The Vital Space effort is focused on the development and implementation of cost effective, innovative hardware and software solutions for the collection, storage, and retrieval of physiological data related to the training, in-flight, and post-flight performance of commercial spaceflight participants. Through strategic partnerships, the Vital Space program provides an integrated physiologic sensor suite with established non-proprietary interfaces for serving the commercial spaceflight market and to quantitatively rate and assess high performance individuals. Vital Space envisions that the development analytics engines for clinical data will be critical to help develop guidelines for risk stratification and eventually clinical prediction rules that can provide insight on potential outcomes for parabolic and commercial space flights. The proposed Vital Space program meshes with several of element of the NASA OCT Human Health, Life Support, and Habitation Systems (HLHS technology area 06) roadmap under the topic of Human Health and Performance (2.3 HHP). Vital Space plans on making the information about the Vital Space System hardware functionality and usability during parabolic flight available via peer reviewed publications, presentation at appropriate venues such as meetings of the Aerospace Medical Association and Next-Generation Suborbital Researchers Conference in addition to NASA centers upon request. We also plan on making an initial anonymous version of the Vital Space database available to NASA and the FAA AST offices. The proposed assessment of device functionality as well as identification of problem areas will ultimately guide efforts for modification and improvement so that these highly capable medical tools can be used effective for physiologic data acquisition for commercial spaceflight participants and researchers during parabolic flight, future commercial space platforms, and other areas that require continuous measurements of health and performance.