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Center Independent Research & Development: GSFC IRAD

Microchip-based monolithic column for high performance liquid chromatography

Completed Technology Project

Project Introduction

We have developed microchip based monolithic columns that can be used for liquid chromatography of small organic molecules, as well as, macromolecules such as proteins and dna. We use in situ chemistry techniques to form a porous structure inside microchannels. This technology addresses the need to perform chemical analysis with high efficiency, superior reproducibility, fast speed and better column stability - all at the same time.

Fabricate the microchannels using DDL facilities. Develop a process for in situ polymerization inside the microchannels and optimize the chemistry Perform separation of organic molecules to demonstrate device capability.

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Project Duration

Technology Maturity (TRL)

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This is a historic project that was completed before the creation of TechPort on October 1, 2012. Available data has been included. This record may contain less data than currently active projects.