{"projectId":93321,"project":{"projectId":93321,"title":"A 3D Printer Enabled, High Performing, Microgravity Compatible, and Versatile Sample Preparation Platform","startDate":"2017-06-09","startYear":2017,"startMonth":6,"endDate":"2017-12-08","endYear":2017,"endMonth":12,"programId":73,"program":{"ableToSelect":false,"acronym":"SBIR/STTR","isActive":true,"description":"<p>The NASA SBIR and STTR programs fund the research, development, and demonstration of innovative technologies that fulfill NASA needs as described in the annual Solicitations and have significant potential for successful commercialization. If you are a small business concern (SBC) with 500 or fewer employees or a non-profit RI such as a university or a research laboratory with ties to an SBC, then NASA encourages you to learn more about the SBIR and STTR programs as a potential source of seed funding for the development of your innovations.</p><p><strong>The SBIR and STTR programs have 3 phases</strong>:</p><ul><li><strong>Phase I</strong> is the opportunity to establish the scientific, technical, and commercial feasibility of the proposed innovation in fulfillment of NASA needs.</li><li><strong>Phase II</strong> is focused on the development, demonstration and delivery of the proposed innovation.</li></ul><p>The SBIR and STTR Phase I contracts last for 6 months with a maximum funding of $125,000, and Phase II contracts last for 24 months with a maximum funding of $750,000 - $1.5 million.</p><ul><li><strong>Phase III</strong> is the commercialization of innovative technologies, products, and services resulting from either a Phase I or Phase II contract. Phase III contracts are funded from sources other than the SBIR and STTR programs and may be awarded without further competition.</li></ul><p><strong>Opportunity for Continued Technology Development Post-Phase II</strong>:</p><p>The NASA SBIR/STTR Program currently has in place two initiatives for supporting its small business partners past the basic Phase I and Phase II elements of the program that emphasize opportunities for commercialization. Specifically, the NASA SBIR/STTR Program has the Phase II Enhancement (Phase II-E) and Phase II eXpanded (Phase II-X) contract options.&nbsp;</p><p><strong>Please review the links below to obtain more information on the SBIR/STTR programs.</strong></p><ul><li><strong><a target=\"_blank\" href=\"http://sbir.gsfc.nasa.gov/sites/default/files/ParticipationGuide.pdf\">Participation Guide</a></strong></li></ul><p>Provides an overview of the SBIR and STTR programs as implemented by NASA</p><ul><li><strong><a href=\"http://sbir.gsfc.nasa.gov/solicitations\">Program Solicitations</a></strong></li></ul><p>Provides access to the annual SBIR/STTR Solicitations containing detailed information on the program eligibility requirements, proposal instructions and research topics and subtopics</p><ul><li><strong><a href=\"http://sbir.gsfc.nasa.gov/prg_sched_anncmnt\">Schedule and Awards</a></strong></li></ul><p>Schedule and links for the SBIR/STTR solicitations and selection announcements</p><ul><li><strong><a href=\"http://sbir.gsfc.nasa.gov/content/additional-sources-assistance\">Sources of Assistance</a></strong></li></ul><p>Federal and non-Federal sources of assistance for small business</p><ul><li><strong><a href=\"http://sbir.gsfc.nasa.gov/abstract_archives\">Awarded Abstracts</a></strong></li></ul><p>Search our complete archive of awarded project abstracts to learn about what NASA has funded</p><ul><li><strong><a href=\"http://sbir.gsfc.nasa.gov/content/frequently-asked-questions\">Frequently Asked Questions</a></strong></li></ul><p>&nbsp;Still have questions? Visit the program FAQs</p>","parentProgram":{"ableToSelect":false,"isActive":true,"description":"Catalyst is a portfolio of early stage programs that specialize in different innovation constituencies and mechanisms to push the state of the art in aerospace technology development","programId":92327,"responsibleMd":{"canUserEdit":false,"locationEdit":false,"organizationRolePretty":"","organizationTypePretty":""},"title":"Catalyst","acronymOrTitle":"Catalyst"},"parentProgramId":92327,"programId":73,"responsibleMd":{"organizationId":4875,"organizationName":"Space Technology Mission Directorate","acronym":"STMD","organizationType":"NASA_Mission_Directorate","canUserEdit":false,"locationEdit":false,"organizationRolePretty":"","organizationTypePretty":"NASA Mission Directorate"},"responsibleMdOffice":4875,"stockImageFileId":36648,"title":"Small Business Innovation Research/Small Business Tech Transfer","acronymOrTitle":"SBIR/STTR"},"description":"AI Biosciences proposes to demonstrate the ability of a microgravity-compatible, compact, light-weight, and automated versatile sample preparation platform (VSPP) that processes samples from various sample matrices (swab, potable water, blood, urine, etc.) to yield high quality nucleic acids for downstream molecular detection and identification in a closed-cartridge system. Its primary function will enable NASA to rapidly identify microorganisms that could affect crew safety. This near-term deployable cartridge and platform system also has the option to perform isothermal and PCR amplification of nucleic acids. This highly flexible system will allow previously complicated, labor-intensive, and time consuming processes to be carried out by a turn-key and closed system using pre-filled cartridges. We have demonstrated on the ground in a laboratory setting that the entire setup for high quality DNA/RNA extraction from urine, whole blood, serum, and saliva can be achieved via simple and reversible retrofitting of a low-cost fused deposition modeling (FDM) based 3D printers ranging from $199 to $750. The VSPP can also be used to capture and purify cell and protein targets. The ability of having a dual-use 3D printer in-flight to carry out sample preparation and additive manufacturing in-flight can be an attractive option in long duration space flights.","benefits":"The ability to carry out sample preparation in microgravity using a small footprint, versatile device and extensible cartridges in an enclosed format will introduce the ability to carry out sample preparation for molecular biology tests from a variety of sample matrices (cell culture, plant tissue, blood, swab, etc.). The unit can also be easily coupled with suitable downstream detection modules to expand its capabilities to include processes such as PCR, isothermal amplification, and sequencing. With the development of proper assays, new applications can be extended to include microbial detection in advanced life support systems, in-vitro testing for infectious diseases during space flight, gene expression analysis for radiation exposure monitoring/studies, and effect of space flight on microbial gene expression and virulence. These processes can be completed inside the Microgravity Sciences Glovebox (MSG) or disposable glove bag to minimize sample transfer or contamination concerns. By offering a medium throughput sample preparation platform, our VSPP unit will enable researchers and companies to carry out in-situ life sciences research inside the ISS with near real-time result capability when coupled with appropriate detection systems.<br /> <br />With advances in molecular diagnostics, life science, and forensics, there will be a vast increase in demand for instrumentation that can handle automated sample preparation in a closed format to eliminate cross-contamination. According to a recent report by Markets and Markets, the global nucleic acid isolation and purification market is expected to reach $3.8 billion USD by 2020. Increasing healthcare expenditure will aid the growth of the nucleic acid isolation and purification market. Our unit also has the capability to carry out molecular detection by isothermal amplification. We see it as a great opportunity to offer at-home healthcare diagnostics. Other applications of this VSPP include environmental monitoring, agriculture, and food production safety.","releaseStatus":"Released","status":"Completed","viewCount":595,"destinationType":["Mars"],"trlBegin":4,"trlCurrent":6,"trlEnd":6,"lastUpdated":"01/22/26","favorited":false,"detailedFunding":false,"projectContacts":[{"contactId":3163995,"canUserEdit":false,"firstName":"Robert","lastName":"Jones","fullName":"Robert Jones","fullNameInverted":"Jones, Robert","email":"Robert.A.Jones@nasa.gov","receiveEmail":"Subscribed_Contact","projectContactRole":"Project_Manager","projectContactId":546823,"projectId":93321,"programContactRolePretty":"","projectContactRolePretty":"Project Manager"},{"contactId":429419,"canUserEdit":false,"firstName":"Season","lastName":"Wong","fullName":"Season Wong","fullNameInverted":"Wong, Season","receiveEmail":"Subscribed_User","projectContactRole":"Principal_Investigator","projectContactId":546824,"projectId":93321,"programContactRolePretty":"","projectContactRolePretty":"Principal Investigator"}],"programContacts":[{"contactId":206378,"canUserEdit":false,"firstName":"Jason","lastName":"Kessler","fullName":"Jason L Kessler","fullNameInverted":"Kessler, Jason L","middleInitial":"L","email":"jason.l.kessler@nasa.gov","receiveEmail":"Subscribed_User","programContactRole":"Program_Director","programContactId":143,"programId":73,"programContactRolePretty":"Program Director","projectContactRolePretty":""},{"contactId":62051,"canUserEdit":false,"firstName":"Carlos","lastName":"Torrez","fullName":"Carlos Torrez","fullNameInverted":"Torrez, Carlos","email":"carlos.torrez@nasa.gov","receiveEmail":"Subscribed_User","programContactRole":"Program_Manager","programContactId":194,"programId":73,"programContactRolePretty":"Program Manager","projectContactRolePretty":""}],"leadOrganization":{"organizationId":4749,"organizationName":"AI Biosciences, Inc.","organizationType":"Industry","city":"College Station","stateTerritoryId":29,"stateTerritory":{"abbreviation":"TX","country":{"abbreviation":"US","countryId":236,"name":"United States"},"countryId":236,"name":"Texas","stateTerritoryId":29,"isTerritory":false},"country":{"abbreviation":"US","countryId":236,"name":"United States"},"countryId":236,"zipCode":"","dunsNumber":"078432725","uei":"J4S6VXC9CK77","cageCode":"6PZP9","congressionalDistrict":"Texas 17","msiCategories":[],"msiData":{},"setAsideData":["Minority-Owned Business","Small Disadvantaged Business (SDB)"],"projectId":93321,"projectOrganizationId":574664,"organizationRole":"Lead_Organization","canUserEdit":false,"locationEdit":false,"organizationRolePretty":"Lead Organization","organizationTypePretty":"Industry"},"otherOrganizations":[{"organizationId":4749,"organizationName":"AI Biosciences, Inc.","organizationType":"Industry","city":"College Station","stateTerritoryId":29,"stateTerritory":{"abbreviation":"TX","country":{"abbreviation":"US","countryId":236,"name":"United States"},"countryId":236,"name":"Texas","stateTerritoryId":29,"isTerritory":false},"country":{"abbreviation":"US","countryId":236,"name":"United States"},"countryId":236,"zipCode":"","dunsNumber":"078432725","uei":"J4S6VXC9CK77","cageCode":"6PZP9","congressionalDistrict":"Texas 17","msiCategories":[],"msiData":{},"setAsideData":["Minority-Owned Business","Small Disadvantaged Business (SDB)"],"projectId":93321,"projectOrganizationId":574664,"organizationRole":"Lead_Organization","canUserEdit":false,"locationEdit":false,"organizationRolePretty":"Lead Organization","organizationTypePretty":"Industry"},{"organizationId":4946,"organizationName":"Jet Propulsion Laboratory","acronym":"JPL","organizationType":"FFRDC_2fUARC","city":"Pasadena","stateTerritoryId":59,"stateTerritory":{"abbreviation":"CA","country":{"abbreviation":"US","countryId":236,"name":"United States"},"countryId":236,"name":"California","stateTerritoryId":59,"isTerritory":false},"country":{"abbreviation":"US","countryId":236,"name":"United States"},"countryId":236,"zipCode":"91109","projectId":93321,"projectOrganizationId":574665,"organizationRole":"Supporting_Organization","canUserEdit":false,"locationEdit":false,"organizationRolePretty":"Supporting Organization","organizationTypePretty":"FFRDC/UARC"}],"primaryTx":{"taxonomyNodeId":11178,"taxonomyRootId":8817,"parentNodeId":11177,"code":"TX06.4.1","title":"Air, Water, Microbial, and Acoustic Sensors","description":"Air, water, microbial, and acoustic sensors monitor the environmental health of aircraft and accurately determine and control the physical, chemical, and biological environments of crewmember living areas and their environmental control systems.","exampleTechnologies":"Atmosphere quality sensors, airborne particle sensor, water quality sensor, biocide sensor, water total organic carbon sensor, microbial sensor, acoustic monitoring","level":3,"hasChildren":false,"selected":false,"isPrimary":true,"hasInteriorContent":true},"primaryTxTree":[[{"taxonomyNodeId":11157,"taxonomyRootId":8817,"code":"TX06","title":"Human Health, Life Support, and Habitation Systems","level":1,"hasChildren":true,"selected":false,"hasInteriorContent":true},{"taxonomyNodeId":11177,"taxonomyRootId":8817,"parentNodeId":11157,"code":"TX06.4","title":"Environmental Monitoring, Safety, and Emergency Response","description":"Environmental monitoring, safety, and emergency response technologies ensure crew health and safety by protecting against spacecraft hazards and ensuring effective response if an accident occurs.","level":2,"hasChildren":true,"selected":false,"hasInteriorContent":true},{"taxonomyNodeId":11178,"taxonomyRootId":8817,"parentNodeId":11177,"code":"TX06.4.1","title":"Air, Water, Microbial, and Acoustic Sensors","description":"Air, water, microbial, and acoustic sensors monitor the environmental health of aircraft and accurately determine and control the physical, chemical, and biological environments of crewmember living areas and their environmental control systems.","exampleTechnologies":"Atmosphere quality sensors, airborne particle sensor, water quality sensor, biocide sensor, water total organic carbon sensor, microbial sensor, acoustic monitoring","level":3,"hasChildren":false,"selected":true,"hasInteriorContent":true}]],"technologyOutcomes":[],"primaryImage":{"file":{"fileExtension":"png","fileId":366271,"presignedUpload":false,"fileSizeString":"0 Byte"},"libraryItemId":365694,"description":"A 3D Printer Enabled, High Performing, Microgravity Compatible, and Versatile Sample Preparation Platform, Phase I Briefing Chart Image","projectId":93321,"publishedDateString":"","entryDateString":"","libraryItemTypePretty":"","modifiedDateString":""},"libraryItems":[{"file":{"fileExtension":"pdf","fileId":366272,"fileName":"SBIR_2017_1_BC_H3_02-9356","fileSize":2518268,"objectId":365695,"objectType":"libraryItemFiles","presignedUpload":false,"fileSizeString":"2.4 MB"},"files":[{"fileExtension":"pdf","fileId":366272,"fileName":"SBIR_2017_1_BC_H3_02-9356","fileSize":2518268,"objectId":365695,"objectType":"libraryItemFiles","presignedUpload":false,"fileSizeString":"2.4 MB"}],"libraryItemId":365695,"title":"Briefing Chart","description":"A 3D Printer Enabled, High Performing, Microgravity Compatible, and Versatile Sample Preparation Platform, Phase I Briefing Chart","libraryItemType":"Document","projectId":93321,"isPrimary":false,"internalOnly":false,"publishedDateString":"","entryDateString":"01/22/25 01:10 AM","libraryItemTypePretty":"Document","modifiedDateString":"01/08/24 08:27 PM"},{"file":{"fileExtension":"png","fileId":366271,"fileName":"SBIR_2017_1_BC_H3_02-9356","fileSize":2505322,"objectId":365694,"objectType":"libraryItemFiles","presignedUpload":false,"fileSizeString":"2.4 MB"},"files":[{"fileExtension":"png","fileId":366271,"fileName":"SBIR_2017_1_BC_H3_02-9356","fileSize":2505322,"objectId":365694,"objectType":"libraryItemFiles","presignedUpload":false,"fileSizeString":"2.4 MB"}],"libraryItemId":365694,"title":"Briefing Chart Image","description":"A 3D Printer Enabled, High Performing, Microgravity Compatible, and Versatile Sample Preparation Platform, Phase I Briefing Chart Image","libraryItemType":"Image","projectId":93321,"isPrimary":true,"internalOnly":false,"publishedDateString":"","entryDateString":"01/22/25 01:10 AM","libraryItemTypePretty":"Image","modifiedDateString":"01/08/24 08:27 PM"}],"states":[{"abbreviation":"CA","country":{"abbreviation":"US","countryId":236,"name":"United States"},"countryId":236,"name":"California","stateTerritoryId":59,"isTerritory":false},{"abbreviation":"TX","country":{"abbreviation":"US","countryId":236,"name":"United States"},"countryId":236,"name":"Texas","stateTerritoryId":29,"isTerritory":false}],"endDateString":"Dec 2017","startDateString":"Jun 2017"}}