{"projectId":8033,"project":{"projectId":8033,"title":"Chromatid Painting for Chromosomal Inversion Detection, Phase I","startDate":"2009-01-22","startYear":2009,"startMonth":1,"endDate":"2009-07-22","endYear":2009,"endMonth":7,"programId":73,"program":{"ableToSelect":false,"acronym":"SBIR/STTR","isActive":true,"description":"<p>The NASA SBIR and STTR programs fund the research, development, and demonstration of innovative technologies that fulfill NASA needs as described in the annual Solicitations and have significant potential for successful commercialization. If you are a small business concern (SBC) with 500 or fewer employees or a non-profit RI such as a university or a research laboratory with ties to an SBC, then NASA encourages you to learn more about the SBIR and STTR programs as a potential source of seed funding for the development of your innovations.</p><p><strong>The SBIR and STTR programs have 3 phases</strong>:</p><ul><li><strong>Phase I</strong> is the opportunity to establish the scientific, technical, and commercial feasibility of the proposed innovation in fulfillment of NASA needs.</li><li><strong>Phase II</strong> is focused on the development, demonstration and delivery of the proposed innovation.</li></ul><p>The SBIR and STTR Phase I contracts last for 6 months with a maximum funding of $125,000, and Phase II contracts last for 24 months with a maximum funding of $750,000 - $1.5 million.</p><ul><li><strong>Phase III</strong> is the commercialization of innovative technologies, products, and services resulting from either a Phase I or Phase II contract. Phase III contracts are funded from sources other than the SBIR and STTR programs and may be awarded without further competition.</li></ul><p><strong>Opportunity for Continued Technology Development Post-Phase II</strong>:</p><p>The NASA SBIR/STTR Program currently has in place two initiatives for supporting its small business partners past the basic Phase I and Phase II elements of the program that emphasize opportunities for commercialization. Specifically, the NASA SBIR/STTR Program has the Phase II Enhancement (Phase II-E) and Phase II eXpanded (Phase II-X) contract options.&nbsp;</p><p><strong>Please review the links below to obtain more information on the SBIR/STTR programs.</strong></p><ul><li><strong><a target=\"_blank\" href=\"http://sbir.gsfc.nasa.gov/sites/default/files/ParticipationGuide.pdf\">Participation Guide</a></strong></li></ul><p>Provides an overview of the SBIR and STTR programs as implemented by NASA</p><ul><li><strong><a href=\"http://sbir.gsfc.nasa.gov/solicitations\">Program Solicitations</a></strong></li></ul><p>Provides access to the annual SBIR/STTR Solicitations containing detailed information on the program eligibility requirements, proposal instructions and research topics and subtopics</p><ul><li><strong><a href=\"http://sbir.gsfc.nasa.gov/prg_sched_anncmnt\">Schedule and Awards</a></strong></li></ul><p>Schedule and links for the SBIR/STTR solicitations and selection announcements</p><ul><li><strong><a href=\"http://sbir.gsfc.nasa.gov/content/additional-sources-assistance\">Sources of Assistance</a></strong></li></ul><p>Federal and non-Federal sources of assistance for small business</p><ul><li><strong><a href=\"http://sbir.gsfc.nasa.gov/abstract_archives\">Awarded Abstracts</a></strong></li></ul><p>Search our complete archive of awarded project abstracts to learn about what NASA has funded</p><ul><li><strong><a href=\"http://sbir.gsfc.nasa.gov/content/frequently-asked-questions\">Frequently Asked Questions</a></strong></li></ul><p>&nbsp;Still have questions? Visit the program FAQs</p>","parentProgram":{"ableToSelect":false,"isActive":true,"description":"Catalyst is a portfolio of early stage programs that specialize in different innovation constituencies and mechanisms to push the state of the art in aerospace technology development","programId":92327,"responsibleMd":{"canUserEdit":false,"locationEdit":false,"organizationRolePretty":"","organizationTypePretty":""},"title":"Catalyst","manageGaps":false,"acronymOrTitle":"Catalyst"},"parentProgramId":92327,"programId":73,"responsibleMd":{"organizationId":4875,"organizationName":"Space Technology Mission Directorate","acronym":"STMD","organizationType":"NASA_Mission_Directorate","canUserEdit":false,"locationEdit":false,"organizationRolePretty":"","organizationTypePretty":"NASA Mission Directorate"},"responsibleMdOffice":4875,"stockImageFileId":36648,"title":"Small Business Innovation Research/Small Business Tech Transfer","manageGaps":false,"acronymOrTitle":"SBIR/STTR"},"description":"We propose a novel approach to the detection of chromosomal inversions.  Transmissible chromosome aberrations (translocations and inversions) have profound genetic effects, such as disrupting regulatory sequences that control gene expression, or creating genetic chimeras.  These chromosome aberrations play a causative role in cancer, and they are induced by radiation.  As such, chromosome aberrations are relevant to three NASA needs, biodosimetry, analysis of astronaut lymphocytes for cumulative radiation damage, and space radiation risk modeling.  Of all structural chromosomal anomalies, inversions -- a reversal of orientation of material within a chromosome -- are the most difficult to detect.  This is especially true of small inversions, most of which are invisible to all current cytogenetic techniques.  Yet small inversions are likely the most transmissible (nonlethal) form of chromosomal damage, so they persist, a feature which lends credence to their use in retrospective biodosimetry.  This Phase 1 project is intended to provide a proof-of-principle demonstration of a new method of molecular cytogenetics that will permit highly sensitive inversion detection.  The project will help us to perfect our bioinformatics strategy for probe design, optimize probe labeling reactions, refine hybridization conditions, and establish a procedure for cost analysis.  In Phase 2, we will scale-up probe production to make whole chromosome analysis possible.  This next step, although conceptually simple, relies entirely on the processes devised and tested in Phase 1.  Moreover efficient, cost-effective probe-making will be essential to commercialization (Phase 3).  The technology readiness level at the end of the Phase 1 contract is expected to be 4-5, i.e. validated in laboratory and relevant environments.","releaseStatus":"Released","status":"Completed","viewCount":695,"destinationType":[],"lastUpdated":"01/27/25","favorited":false,"detailedFunding":false,"projectContacts":[],"programContacts":[{"contactId":206378,"canUserEdit":false,"firstName":"Jason","lastName":"Kessler","fullName":"Jason L Kessler","fullNameInverted":"Kessler, Jason L","middleInitial":"L","email":"jason.l.kessler@nasa.gov","receiveEmail":"Subscribed_User","programContactRole":"Program_Director","programContactId":143,"programId":73,"programContactRolePretty":"Program Director","projectContactRolePretty":""},{"contactId":62051,"canUserEdit":false,"firstName":"Carlos","lastName":"Torrez","fullName":"Carlos Torrez","fullNameInverted":"Torrez, Carlos","email":"carlos.torrez@nasa.gov","receiveEmail":"Subscribed_User","programContactRole":"Program_Manager","programContactId":194,"programId":73,"programContactRolePretty":"Program Manager","projectContactRolePretty":""}],"leadOrganization":{"organizationId":4853,"organizationName":"Johnson Space Center","acronym":"JSC","organizationType":"NASA_Center","city":"Houston","stateTerritoryId":29,"stateTerritory":{"abbreviation":"TX","country":{"abbreviation":"US","countryId":236,"name":"United States"},"countryId":236,"name":"Texas","stateTerritoryId":29,"isTerritory":false},"country":{"abbreviation":"US","countryId":236,"name":"United States"},"countryId":236,"zipCode":"77058","projectId":8033,"projectOrganizationId":22425,"organizationRole":"Lead_Organization","canUserEdit":false,"locationEdit":false,"organizationRolePretty":"Lead Organization","organizationTypePretty":"NASA Center"},"otherOrganizations":[{"organizationId":4853,"organizationName":"Johnson Space Center","acronym":"JSC","organizationType":"NASA_Center","city":"Houston","stateTerritoryId":29,"stateTerritory":{"abbreviation":"TX","country":{"abbreviation":"US","countryId":236,"name":"United States"},"countryId":236,"name":"Texas","stateTerritoryId":29,"isTerritory":false},"country":{"abbreviation":"US","countryId":236,"name":"United States"},"countryId":236,"zipCode":"77058","projectId":8033,"projectOrganizationId":22425,"organizationRole":"Lead_Organization","canUserEdit":false,"locationEdit":false,"organizationRolePretty":"Lead Organization","organizationTypePretty":"NASA Center"},{"organizationId":3785,"organizationName":"KromaTiD, Inc.","organizationType":"Industry","city":"Fort Collins","stateTerritoryId":15,"stateTerritory":{"abbreviation":"CO","country":{"abbreviation":"US","countryId":236,"name":"United States"},"countryId":236,"name":"Colorado","stateTerritoryId":15,"isTerritory":false},"country":{"abbreviation":"US","countryId":236,"name":"United States"},"countryId":236,"zipCode":"80524-3151","uei":"YTHLMBHDYM55","cageCode":"4U2V4","congressionalDistrict":"Colorado 02","projectId":8033,"projectOrganizationId":8975,"organizationRole":"Supporting_Organization","canUserEdit":false,"locationEdit":false,"organizationRolePretty":"Supporting Organization","organizationTypePretty":"Industry"}],"primaryTx":{"taxonomyNodeId":11270,"taxonomyRootId":8817,"parentNodeId":11265,"code":"TX10.1.5","title":"Event and Trend Identification","description":"Event and trend identification technologies analyze data about the environment or system to identify events and trends that may affect future states, operations, and decision-making.","exampleTechnologies":"Characterization of system performance, prediction of weather events, prediction of air traffic, science data analytics for decision making","level":3,"hasChildren":false,"selected":false,"isPrimary":true,"hasInteriorContent":true},"primaryTxTree":[[{"taxonomyNodeId":11264,"taxonomyRootId":8817,"code":"TX10","title":"Autonomous Systems","level":1,"hasChildren":true,"selected":false,"hasInteriorContent":true},{"taxonomyNodeId":11265,"taxonomyRootId":8817,"parentNodeId":11264,"code":"TX10.1","title":"Situational and Self-Awareness Technologies","description":"Situational and self-awareness technologies interrogate, identify, and evaluate both the state of the environment and the state of the system. 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