{"project": { "benefits": "

Kidney stones have long been near the top of NASA's list of concerns; mitigating Gap 4.02 medical condition Nephrolithiasis is a shall for all missions beyond the International Space Station (ISS). Likewise, stones have plagued humans since ancient Egypt. Currently, one in eleven Americans has suffered from stones -- more than have diabetes or cardiovascular disease. Dehydration, stasis, and bone demineralization are strong contributors to kidney stones, and occur in microgravity, increasing the risk of stones in space. Stones are often debilitating, and pilots cannot fly with stones. Stones occurred on a Russian space mission, and the mission was nearly aborted before the stone passed. Over 30 stones have occurred shortly following even short duration space flights. NASA has collected compelling evidence for concern on its website https://humanresearchroadmap.nasa.gov/Evidence/medicalConditions/Nephrolithiasis.pdf<\/a> . Additionally, since the website publication, the total number of astronaut stone episodes has more than doubled, and a drug introduced to combat visual impairment/intracranial pressure has exacerbated the risk. Science, experience, and the negative medical consequences support concern for the risk of stones in space. NASA and NSBRI have focused considerable attention on stones and made progress. However, there are many types of stone disease, and it is unlikely that stone disease will ever be completely prevented on Earth or in space. We propose a way to prevent or minimize the consequences of any stones that form while in space. The treatment for most kidney stones is to encourage natural passage. To quote NASA's expectations in space Based on current Lifetime Surveillance of Astronaut Health (LSAH) data, 80 to 85% of in-flight cases of nephrolithiasis are expected to be best case scenarios (defined as a renal stone that responds to conservative treatment, e.g., analgesics and hydration), and 15 to 20% would be worst case scenarios (defined as a renal stone that does not respond to conservative treatment, e.g., requires lithotripsy or surgical treatment). Even surgery leaves residual fragments that must pass. Our technology provides the capability to reposition stones within the kidney and ureter, which will enhance conservative treatment or surgery by accelerating and facilitating passage of stones or fragments. However, this does not have to be the only use. The technology can also be used to reposition a stone to a non-obstructing location within the kidney to postpone surgery or to accelerate passage through the ureter, as proposed here. Finally, the technology proposed in this grant also provides the capability to comminute the stone as in shock wave lithotripsy (SWL) with what we call burst wave lithotripsy (BWL).<\/p>", "programDirectors": {"programDirector": "William Paloski"}, "coInvestigators": {"coInvestigator": [ "Lawrence Crum", "Oleg Sapozhnikov", "Mathew Sorensen", "Yak-nam Wang", "Vera Khohklova", "Wayne Kreider", "Jonathan David Harper" ]}, "responsibleProgram": "Human Research Program", "workLocations": {"workLocation": "Washington"}, "website": "https://humanresearchroadmap.nasa.gov/", "endDate": "Dec 2016", "primaryTas": {"technologyAreas": { "code": 6, "name": "Human Health, Life Support, and Habitation Systems", "id": 3244 }}, "destinations": {"destination": [ "The Moon", "Mars" ]}, "description": "

1. Specific aims<\/p>

We will refine and validate probes to integrate with the NASA Flexible Ultrasound System (FUS) to address Exploration Medical Capabilities (ExMC) Gap 4.02 Nephrolithiasis.<\/p>

AIM 1. Refine ultrasound probes to detect, reposition, and fragment kidney stones. AIM 2. Validate probes to visualize, reposition, and fragment stones. AIM 3. Refine and validate imaging to guide therapy.<\/p>

2. Key Findings<\/p>

A probe and software to image and reposition kidney stones were developed and integrated on a radiation hardened flexible ultrasound system (FUS) and demonstrated effectively on human subjects. A probe to image, reposition, and fragment stones was designed, fabricated, and integrated into an FUS and is currently in clinical trials to expel stone fragments. Software was developed and integrated on an FUS and validated in human subjects to improve kidney stone detection and size determination. The ability to reposition stones was also integrated into the partially completed NASA FUS with the NASA FUS probes and demonstrated. The work has garnered attention. Reports have been sent to NSBRI (National Space Biomedical Research Institute), FDA (Food & Drug Administration), NIH (National Institutes of Health), NASA, and OMB (Office of Management and Budget). Demonstrations have been conducted at American Urological Association (AUA) annual meetings each year, Congress twice, and several other professional societies. Over 40 papers have been published. Over 40 patent applications have been submitted. Students, residents, and fellows have trained on the project. Technology developed in this research has been licensed to a spin-off company SonoMotion Inc.<\/p>

3. Impact<\/p>

We have invented a technology to reposition kidney stones and demonstrated it works in people. In four of the cases, what appeared as one large stone on x-ray was two or three small passable stones. This had direct diagnostic benefit to these subjects and changed their course of treatment. In four other subjects, we moved stones out of the kidney, which they passed. This result was a direct therapeutic benefit to these subjects. One subject felt relief from a painful obstructing stone. We have shown we can produce a working prototype, develop sufficiently high-quality imaging to guide treatment, train new users, and conduct a successful clinical trial. We refined the system design, submitted for publication in vitro results quantifying the improvement, and entered a second clinical trial. The refined design also has the capability to fragment stones. This design is being commercialized. Specifically, we have now implemented our technologies with different probes making it efficient to add the probes NASA selects or to continue to refine the probes we can provide. Our imaging software can be added to an FUS or commercial imager. Our pushing capability has been added as a software upgrade to the FUS. Our advanced repositioning and fragmenting probe is readily integrated with any standard or FUS imager with minimal additional mass and software change to the system. Our final system and the system being commercialized, when validated in human in a flight analog, largely close the gap of nephrolithiasis or exploration mission and extends application to the emergency department on Earth. Our new stone sizing technique can be used on any imager by any user to improve the accuracy of stone size determination with ultrasound. Overestimated stone size leads to unnecessary surgeries, and underestimated stone size leads to obstructions and ER (emergency room) visits. Stone size similarly determines risk and course of action in space.<\/p>

4. Proposed Research<\/p>

We are conducting a clinical trial of S-mode software for automatic stone detection and stone sizing. We are conducting a clinical trial of expelling stone fragments. We have received approval and set up the infrastructure for an test of ultrasonic propulsion in an Emergency Department (ED) analog to a space emergency, and seek funding for that trial. We are testing safety and effectiveness in clinical simulation in animal studies of stone breaking to add this capability to our ED trial. The technology is also being tested for gallstones.<\/p>", "technologyMaturityCurrent": 6, "title": "Prevention of Renal Stone Complications in Space Exploration", "leadOrganization": { "acronym": "NSBRI", "name": "National Space Biomedical Research Institute", "type": "Industry" }, "technologyMaturityEnd": 6, "additionalTas": "", "principalInvestigators": {"principalInvestigator": "Michael R Bailey"}, "lastUpdated": "2018-11-01", "supportingOrganizations": {"organization": [ { "name": "Lomonosov Moscow State University", "type": "Academic" }, { "city": "Seattle", "name": "University of Washington", "state": "WA", "type": "Academic" } ]}, "library": {"libraryItem": [ { "publishedBy": "", "description": "

Lee F, Hsi R, Sorensen M, Paun M, Dunmire B, Liu Z, Bailey M, Harper J. "Shockwave Lithotripsy with Renoprotective Pause Is Associated with Renovascular Vasoconstriction in Humans." 2014 Annual Meeting of the American Urological Association, Orlando, FL, May 16-21, 2014. Journal of Urology 2014 Apr;19(4 Suppl):e203. http://dx.doi.org/10.1016/j.juro.2014.02.741<\/a> , Apr-2014<\/p>", "files": "", "id": 46338, "title": "Abstracts for Journals and Proceedings", "type": "Story" }, { "publishedBy": "", "description": "

Bailey MR, Wang YN, Simon J, Hsi RS, Harper JD, Sorensen MD, Starr F, Paun M, Cunitz B, Liggitt HD, Evan AP, McAteer JA. "Ultrasonic propulsion of kidney stones." American Urological Association (AUA) Annual Meeting, San Diego, CA, May 4-8, 2013. Invited plenary presentation. AUA Annual Meeting, San Diego, CA, May 4-8, 2013., May-2013<\/p>", "files": "", "id": 46334, "title": "Abstracts for Journals and Proceedings", "type": "Story" }, { "publishedBy": "", "description": "

Crum L, Cunitz BW, Dunmire B, Harper J, Kaczkowski P, Kucewicz J, Lu W, Paun M, Sapozhnikov O, Simon J, Sorensen MD, Starr F, Wang YN, Bailey MR. "Recent developments in therapeutic ultrasound: Kidney stone imaging and repositioning by ultrasound." Opening Plenary Paper at the 2013 International Congress on Ultrasonics, Singapore, May 2-5, 2013. 2013 International Congress on Ultrasonics, Singapore, May 2-5, 2013., May-2013<\/p>", "files": "", "id": 46336, "title": "Abstracts for Journals and Proceedings", "type": "Story" }, { "publishedBy": "", "description": "

Bailey M, Dunmire B, Cunitz B, Harper J, Lee F, Lingeman J, Sorensen M. "Preliminary results of the initial human clinical trial of focused ultrasound to reposition kidney stones. stones" Oral presentation. 4th International Symposium Current and Future Applications of Focused Ultrasound 2014, Washington, DC, October 2014. Journal of Therapeutic Ultrasound. 2015 Jun;3(Suppl 1):O71. http://dx.doi.org/10.1186/2050-5736-3-S1-O71<\/a> ; PMCID: PMC4489637 , Jun-2015<\/p>", "files": "", "id": 46333, "title": "Abstracts for Journals and Proceedings", "type": "Story" }, { "publishedBy": "", "description": "

Bailey M, Cunitz B, Dunmire B, Wang YN, Maxwell A, Sapozhnikov O, Harper J, Sorensen M, Hsi R, Lee F, Crum L. "Stone Specific Ultrasound Mode for the Diagnoses and Treatment of Kidney Stones in Space." 85th Annual Scientific Meeting, Aerospace Medical Association, San Diego, CA, May 10-15, 2014. Aviation, Space, and Environmental Medicine. 2014 Mar;85(3):318-9. Abstract #357. See http://www.ingentaconnect.com/content/asma/asem/2014/00000085/00000003<\/a> for searching. , Mar-2014<\/p>", "files": "", "id": 46332, "title": "Abstracts for Journals and Proceedings", "type": "Story" }, { "publishedBy": "", "description": "

Crum LA. "Recent advances in medical ultrasound." APS (American Physical Society) March Meeting 2014, Denver, CO, March 3-7, 2014. Bulletin of the American Physical Society. 2014 Mar;59(1):Abstract ID: BAPS.2014.MAR.M23.4. http://meetings.aps.org/link/BAPS.2014.MAR.M23.4<\/a> ; accessed 6/4/2014., Mar-2014<\/p>", "files": "", "id": 46335, "title": "Abstracts for Journals and Proceedings", "type": "Story" }, { "publishedBy": "", "description": "

Janssen KM, Brand TC, Bailey MR, Cunitz BW, Sorensen MD, Harper JD, Dunmire B. "Effect of stone size and composition on ultrasonic propulsion in vitro." 2017 American Urological Association Annual Meeting, Boston, MA, May 12-16, 2017. Journal of Urology. 2017 Apr;197(4 Suppl):e835. (2017 Annual Meeting Program Abstracts, AUA Annual Meeting, Boston, MA, May 12-16, 2017.) https://doi.org/10.1016/j.juro.2017.02.1951<\/a> , Apr-2017<\/p>", "files": "", "id": 46337, "title": "Abstracts for Journals and Proceedings", "type": "Story" }, { "publishedBy": "", "description": "

Maxwell AD, Cunitz BW, Kreider W, Sapozhnikov OA, Hsi RS, Harper JD, Bailey MR, Sorensen MD. "Fragmentation of kidney stones in vitro by focused ultrasound bursts without shock waves." 166th Meeting of the Acoustical Society of America, San Francisco, CA, December 2-6, 2013. J Acoust Soc Am. 2013 Nov;134(5):4183. http://dx.doi.org/10.1121/1.4831340<\/a> , Nov-2013<\/p>", "files": "", "id": 46339, "title": "Abstracts for Journals and Proceedings", "type": "Story" }, { "publishedBy": "", "description": "

Sorensen MD, Bailey MR. "Shock Wave Lithotripsy: Application and future direction." Scientific American. 2017 in press as of May 2017., May-2017<\/p>", "files": "", "id": 46340, "title": "Articles in Other Journals or Periodicals", "type": "Story" }, { "publishedBy": "", "description": "

Simon JC, Wang YN, Cunitz BW, Thiel J, Starr F, Liu Z, Bailey MR. "Effect of carbon dioxide on the twinkling artifact in ultrasound imaging of kidney stones: A pilot study." Ultrasound Med Biol. 2017 May;43(5):877-83. Epub 2017 Feb 9. http://dx.doi.org/10.1016/j.ultrasmedbio.2016.12.010<\/a> ; PubMed PMID: 28190622; PubMed Central PMCID: PMC5385287, May-2017<\/p>", "files": "", "id": 46384, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Sapozhnikov O, Lu W, Bailey M, Kaczkowski P, Crum L. "Bubbles trapped on the surface of kidney stones as a cause of the twinkling artifact in ultrasound imaging." Proceedings of Meetings on Acoustics. 2013 Jun;19(1):075033. http://dx.doi.org/10.1121/1.4800292<\/a> , Jun-2013<\/p>", "files": "", "id": 46378, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Brisbane W, Bailey MR, Sorensen MD. "An overview of kidney stone imaging techniques." Nat Rev Urol. 2016 Nov;13(11):654-62. Epub 2016 Aug 31. Review. http://dx.doi.org/10.1038/nrurol.2016.154<\/a> ; PubMed PMID: 27578040, Nov-2016<\/p>", "files": "", "id": 46345, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Bailey MR, Wang Y-N, Simon JC, Cunitz BW, Harper JD, Hsi RS, Starr F, Paun M, Dunmire B, Sapozhnikov OA, Crum LA, Sorensen MD. "Acoustic radiation force to reposition kidney stones." Proceedings of Meetings on Acoustics. 2013 Jun;19(1):045016. http://dx.doi.org/10.1121/1.4799599<\/a> , Jun-2013<\/p>", "files": "", "id": 46344, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Bailey M, Cunitz B, Dunmire B, Paun M, Lee F, Ross S, Lingeman J, Coburn M, Wessells H, Sorensen M, Harper J. "Ultrasonic propulsion of kidney stones: preliminary results of human feasibility study." IEEE Int Ultrason Symp. 2014 Sep 3;2014:511-4. http://dx.doi.org/10.1109/ULTSYM.2014.0126<\/a> ; PubMed PMID: 26203347; PubMed Central PMCID: PMC4507572, Sep-2014<\/p>", "files": "", "id": 46341, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Harper JD, Dunmire B, Wang YN, Simon JC, Liggitt D, Paun M, Cunitz BW, Starr F, Bailey MR, Penniston KL, Lee FC, Hsi RS, Sorensen MD. "Preclinical safety and effectiveness studies of ultrasonic propulsion of kidney stones." Urology. 2014 Aug;84(2):484-9. http://dx.doi.org/10.1016/j.urology.2014.04.041<\/a> ; PubMed PMID: 24975708; PubMed Central PMCID: PMC4304777, Aug-2014<\/p>", "files": "", "id": 46355, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Janssen KM, Brand TC, Bailey MR, Cunitz BW, Harper JD, Sorensen MD, Dunmire B. "Effect of stone size and composition on ultrasonic propulsion ex vivo." Urology. 2018 Jan;111:225-9. Epub 2017 Sep 28. https://doi.org/10.1016/j.urology.2017.09.013<\/a> ; PubMed PMID: 28964820, Jan-2018<\/p>", "files": "", "id": 46358, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Kreider W, Maxwell AD, Khokhlova TD, Simon JC, Khokhlova VA, Sapozhnikov OA, Bailey MR. "Rectified growth of histotripsy bubbles." Proceedings of Meetings on Acoustics. 2013 Jun;19(1):075035. http://dx.doi.org/10.1121/1.4800326,<\/a> Jun-2013<\/p>", "files": "", "id": 46364, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

May PC, Kreider W, Maxwell AD, Wang YN, Cunitz BW, Blomgren PM, Johnson C, Park JSH, Bailey MR, Lee D, Harper JD, Sorensen MD. "Detection and evaluation of renal injury in burst wave lithotripsy using ultrasound and magnetic resonance imaging." Journal of Endourology. 2017 Aug;31(8):786-92. Epub 2017 May 18. http://dx.doi.org/10.1089/end.2017.0202<\/a> ; PubMed PMID: 28521550, Aug-2017<\/p>", "files": "", "id": 46373, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Simon JC, Dunmire B, Bailey MR, Sorensen MD. "Developing complete ultrasonic management of kidney stones for spaceflight." J Space Safety Eng. 2016 Sep;3(2):50-7. Review. http://dx.doi.org/10.1016/S2468-8967(16)30018-0<\/a> , Sep-2016<\/p>", "files": "", "id": 46379, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Cunitz B, Dunmire B, Paun M, Sapozhnikov O, Kucewicz J, Hsi R, Lee F, Sorensen M, Harper J, Bailey M. "Improved detection of kidney stones using an optimized doppler imaging sequence." IEEE Int Ultrason Symp. 2014 Sep 3;2014:452-5. http://dx.doi.org/10.1109/ULTSYM.2014.0112<\/a> ; PubMed PMID: 26203346; PubMed Central PMCID: PMC4507569, Sep-2014<\/p>", "files": "", "id": 46347, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Cunitz BW, Dunmire B, Bailey MR. "Characterizing the acoustic output of an ultrasonic propulsion device for urinary stones." IEEE Trans Ultrason Ferroelectr Freq Control. 2017 Dec;64(12):1818-27. Epub 2017 Oct 2. https://doi.org/10.1109/TUFFC.2017.2758647<\/a> ; PubMed PMID: 28981413; PubMed Central PMCID: PMC5733808, Dec-2017<\/p>", "files": "", "id": 46348, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Cunitz BW, Harper JD, Sorensen MD, Haider Y, Thiel J, May PC, Liu Z, Bailey MR, Dunmire B, Bruce M. "Quantification of renal stone contrast with ultrasound in human subjects." J Endourol. 2017 Nov;31(11):1123-30. https://doi.org/10.1089/end.2017.0404<\/a> ; PubMed PMID: 28847171; PubMed Central PMCID: PMC5695736 [reported originally in May 2017 as "in review"] , Nov-2017<\/p>", "files": "", "id": 46349, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Dunmire B, Harper JD, Cunitz BW, Lee FC, Hsi R, Liu Z, Bailey MR, Sorensen MD. "Use of the acoustic shadow width to determine kidney stone size with ultrasound." J Urol. 2016 Jan;195(1):171-7. Epub 2015 Aug 22. http://dx.doi.org/10.1016/j.juro.2015.05.111<\/a> ; PubMed PMID: 26301788; PubMed Central PMCID: PMC4821497, Jan-2016<\/p>", "files": "", "id": 46351, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Dunmire B, Lee FC, Hsi RS, Cunitz BW, Paun M, Bailey MR, Sorensen MD, Harper JD. "Tools to improve the accuracy of kidney stone sizing with ultrasound." J Endourol. 2015 Feb;29(2):147-52. Epub 2014 Sep 17. http://dx.doi.org/10.1089/end.2014.0332<\/a> ; PubMed PMID: 25105243; PubMed Central PMCID: PMC4313404, Feb-2015<\/p>", "files": "", "id": 46352, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Harper JD, Cunitz BW, Dunmire B, Lee FC, Sorensen MD, Hsi RS, Thiel J, Wessells H, Lingeman JE, Bailey MR. "First-in-human clinical trial of ultrasonic propulsion of kidney stones." J Urol. 2016 Apr;195(4 Pt 1):956-64. Epub 2015 Oct 30. http://dx.doi.org/10.1016/j.juro.2015.10.131<\/a> ; PubMed PMID: 26521719; PubMed Central PMCID: PMC4851928, Apr-2016<\/p>", "files": "", "id": 46354, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Karzova MM, Yuldashev PV, Sapozhnikov OA, Khokhlova VA, Cunitz BW, Kreider W, Bailey MR. "Shock formation and nonlinear saturation effects in ultrasound field of a diagnostic curvilinear probe." J Acoust Soc Am. 2017 Apr;141(4):2327. http://dx.doi.org/10.1121/1.4979261<\/a> ; PubMed PMID: 28464662, Apr-2017<\/p>", "files": "", "id": 46360, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Maxwell AD, Cunitz BW, Kreider W, Sapozhnikov OA, Hsi RS, Harper JD, Bailey MR, Sorensen MD. "Fragmentation of urinary calculi in vitro by burst wave lithotripsy." J Urol. 2015 Jan;193(1):338-44. Epub 2014 Aug 9. http://dx.doi.org/10.1016/j.juro.2014.08.009<\/a> ; PubMed PMID: 25111910; PubMed Central PMCID: PMC4384893, Jan-2015<\/p>", "files": "", "id": 46368, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Maxwell AD, Hsi RS, Bailey MR, Casale P, Lendvay TS. "Noninvasive ureterocele puncture using pulsed focused ultrasound: An in vitro study." J Endourol. 2014 Mar;28(3):342-6. Epub 2013 Dec 27. http://dx.doi.org/10.1089/end.2013.0528<\/a> ; PubMed PMID: 24171441; PubMed Central PMCID: PMC3929044, Mar-2014<\/p>", "files": "", "id": 46369, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Rosnitskiy PB, Yuldashev PV, Sapozhnikov OA, Maxwell AD, Kreider W, Bailey MR, Khokhlova VA. "Design of HIFU transducers for generating specified nonlinear ultrasound fields." IEEE Trans Ultrason Ferroelectr Freq Control. 2017 Feb;64(2):374-90. http://dx.doi.org/10.1109/TUFFC.2016.2619913<\/a> ; PubMed PMID: 27775904; PubMed Central PMCID: PMC5300962, Feb-2017<\/p>", "files": "", "id": 46377, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Simon JC, Sapozhnikov OA, Kreider W, Breshock M, Williams JC, Bailey MR. "The role of trapped bubbles in kidney stone detection with the color Doppler ultrasound twinkling artifact." Phys Med Biol. 2018 Jan 9;63(2):025011. https://doi.org/10.1088/1361-6560/aa9a2f<\/a> ; PubMed PMID: 29131810; PubMed Central PMCID: PMC5791757, Jan-2018<\/p>", "files": "", "id": 46382, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Wang Y-N, Simon JC, Cunitz B, Starr F, Paun M, Liggitt D, Evan A, McAteer J, Williams J, Liu Z, Kaczkowski P, Hsi R, Sorensen M, Harper J, Bailey MR. "Ultrasound intensity to propel stones from the kidney is below the threshold for renal injury." Proceedings of Meetings on Acoustics. 2013 Jun;19(1):075066. http://dx.doi.org/10.1121/1.4800361,<\/a> Jun-2013<\/p>", "files": "", "id": 46386, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Dai JC, Dunmire B, Sternberg KM, Liu Z, Larson T, Thiel J, Chang HC, Harper JD, Bailey MR, Sorensen MD. "Retrospective comparison of measured stone size and posterior acoustic shadow width in clinical ultrasound images." World J Urol. 2018 May;36(5):727-32. Epub 2017 Dec 14. https://doi.org/10.1007/s00345-017-2156-8<\/a> ; PubMed PMID: 29243111 [reported originally in May 2017 as Epub ahead of print], May-2018<\/p>", "files": "", "id": 46350, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Connors BA, Evan AP, Blomgren PM, Hsi RS, Harper JD, Sorensen MD, Wang YN, Simon JC, Paun M, Starr F, Cunitz BW, Bailey MR, Lingeman JE. "Comparison of tissue injury from focused ultrasonic propulsion of kidney stones versus extracorporeal shock wave lithotripsy." J Urol. 2014 Jan;191(1):235-41. Epub 2013 Aug 2. http://dx.doi.org/10.1016/j.juro.2013.07.087<\/a> ; PubMed PMID: 23917165; PubMed Central PMCID: PMC3865142, Jan-2014<\/p>", "files": "", "id": 46346, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Ghanem MA, Maxwell AD, Kreider W, Cunitz BW, Khokhlova VA, Sapozhnikov OA, Bailey MR. "Field characterization and compensation of vibrational non-uniformity for a 256-element focused ultrasound phased array." IEEE Trans Ultrason Ferroelectr Freq Control. 2018 Jun 27. [Epub ahead of print] https://doi.org/10.1109/TUFFC.2018.2851188<\/a> ; PubMed PMID: 29994675, Jun-2018<\/p>", "files": "", "id": 46353, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Kreider W, Yuldashev PV, Sapozhnikov OA, Farr N, Partanen A, Bailey MR, Khokhlova VA. "Characterization of a multi-element clinical HIFU system using acoustic holography and nonlinear modeling." IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control. 2013 Aug;60(8):1683-98. http://dx.doi.org/10.1109/TUFFC.2013.2750<\/a> , Aug-2013<\/p>", "files": "", "id": 46365, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

May PC, Haider Y, Dunmire B, Cunitz BW, Thiel J, Liu Z, Bruce M, Bailey MR, Sorensen MD, Harper JD. "Stone-mode ultrasound for determining renal stone size." J Endourol. 2016 Sep;30(9):958-62. http://dx.doi.org/10.1089/end.2016.0341<\/a> ; PubMed PMID: 27393000; PubMed Central PMCID: PMC5031098, Sep-2016<\/p>", "files": "", "id": 46372, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Simon JC, Sapozhnikov OA, Wang YN, Khokhlova VA, Crum LA, Bailey MR. "Investigation into the mechanisms of tissue atomization by high-intensity focused ultrasound." Ultrasound Med Biol. 2015 May;41(5):1372-85. http://dx.doi.org/10.1016/j.ultrasmedbio.2014.12.022<\/a> ; PubMed PMID: 25662182; PubMed Central PMCID: PMC4398613, May-2015<\/p>", "files": "", "id": 46383, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Wang YN, Simon JC, Cunitz BW, Starr FL, Paun M, Liggitt DH, Evan AP, McAteer JA, Liu Z, Dunmire B, Bailey MR. "Focused ultrasound to displace renal calculi: threshold for tissue injury." J Ther Ultrasound. 2014 Mar 31;2:5. eCollection 2014. http://dx.doi.org/10.1186/2050-5736-2-5<\/a> ; PubMed PMID: 24921046; PubMed Central PMCID: PMC4036593, Mar-2014<\/p>", "files": "", "id": 46387, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Bailey MR. "Evaluation of renal calculi passage while riding a roller coaster. (Comment on Mitchell and Wartinger article, 'Validation of a functional pyelocalyceal renal model for the evaluation of renal calculi passage while riding a roller coaster.' PubMed PMID: 27669068 )" Journal of the American Osteopathic Association. 2017 Jun 1;117(6):349-50. https://doi.org/10.7556/jaoa.2017.069<\/a> ; PubMed PMID: 28556853, Jun-2017<\/p>", "files": "", "id": 46343, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Hsi RS, Dunmire B, Cunitz BW, He X, Sorensen MD, Harper JD, Bailey MR, Lendvay TS. "Content and face validation of a curriculum for ultrasonic propulsion of calculi in a human renal model." J Endourol. 2014 Apr;28(4):459-63. http://dx.doi.org/10.1089/end.2013.0589<\/a> ; PubMed PMID: 24228719; PubMed Central PMCID: PMC3961775, Apr-2014<\/p>", "files": "", "id": 46357, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Maxwell AD, Yuldashev PV, Kreider W, Khokhlova TD, Schade GR, Hall TL, Sapozhnikov OA, Bailey MR, Khokhlova VA. "A prototype therapy system for transcutaneous application of boiling histotripsy." IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control. 2017 Oct;64(10):1542-1557. https://doi.org/10.1109/TUFFC.2017.2739649<\/a> ; PubMed PMID: 28809681 [reported originally in May 2017 as in press], Oct-2017<\/p>", "files": "", "id": 46370, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Simon JC, Sapozhnikov OA, Khokhlova VA, Crum LA, Bailey MR. "Ultrasonic atomization of liquids in drop chain acoustic fountains." J Fluid Mech. 2015 Mar;766:129-46. http://dx.doi.org/10.1017/jfm.2015.11<\/a> ; PubMed PMID: 25977591; PubMed Central PMCID: PMC4428615, Mar-2015<\/p>", "files": "", "id": 46380, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Oweis GF, Dunmire BL, Cunitz BW, Bailey MR. "Non-invasive measurement of the temperature rise in tissue surrounding a kidney stone subjected to ultrasonic propulsion." Conf Proc IEEE Eng Med Biol Soc. 2015 Aug;2015:2576-9. http://dx.doi.org/10.1109/EMBC.2015.7318918<\/a> ; PubMed PMID: 26736818; PubMed Central PMCID: PMC4832570, Aug-2015<\/p>", "files": "", "id": 46374, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Bailey M, Lee F, Hsi R, Paun M, Dunmire B, Liu Z, Sorensen M, Harper J. "Shockwave lithotripsy with renoprotective pause is associated with renovascular vasoconstriction in humans." IEEE Int Ultrason Symp. 2014 Sep 3;2014:1013-6. http://dx.doi.org/10.1109/ULTSYM.2014.0248<\/a> ; PubMed PMID: 26203348; PubMed Central PMCID: PMC4507567, Sep-2014<\/p>", "files": "", "id": 46342, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Khokhlova TD, Haider YA, Maxwell AD, Kreider W, Bailey MR, Khokhlova VA. "Dependence of boiling histotripsy treatment efficiency on HIFU frequency and focal pressure levels." Ultrasound Med Biol. 2017 Sep;43(9):1975-85. Epub 2017 Jun 20. https://doi.org/10.1016/j.ultrasmedbio.2017.04.030<\/a> ; PubMed PMID: 28641910, Sep-2017<\/p>", "files": "", "id": 46361, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Khokhlova TD, Wang YN, Simon JC, Cunitz BW, Starr F, Paun M, Crum LA, Bailey MR, Khokhlova VA. "Ultrasound-guided tissue fractionation by high intensity focused ultrasound in an in vivo porcine liver model." Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8161-6. http://dx.doi.org/10.1073/pnas.1318355111<\/a> ; PubMed PMID: 24843132 ; PubMed Central PMCID: PMC4050569 , Jun-2014<\/p>", "files": "", "id": 46362, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Lee FC, Hsi RS, Sorensen MD, Dunmire B, Liu Z, Bailey MR, Harper JD. "Renal vasoconstriction occurs early during clinical SWL using a renal protection protocol." J Endourol. 2015 Aug 3. [Epub ahead of print] PubMed PMID: 26239232, Aug-2015<\/p>", "files": "", "id": 46366, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Lee FC, Hsi RS, Sorensen MD, Paun M, Dunmire B, Liu Z, Bailey M, Harper JD. "Renal vasoconstriction occurs early during shockwave lithotripsy in humans." J Endourol. 2015 Dec;29(12):1392-5. Epub Aug 2015. http://dx.doi.org/10.1089/end.2015.0315<\/a> ; PubMed PMID: 26239232; PubMed Central PMCID: PMC4677566, Dec-2015<\/p>", "files": "", "id": 46367, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

May PC, Bailey MR, Harper JD. "Ultrasonic propulsion of kidney stones. (Technological Innovations in Urologic Surgery section)" Curr Opin Urol. 2016 May;26(3):264-70. Review. http://dx.doi.org/10.1097/MOU.0000000000000276<\/a> ; PubMed PMID: 26845428; PubMed Central PMCID: PMC4821680, May-2016<\/p>", "files": "", "id": 46371, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Poliachik SL, Khokhlova TD, Wang YN, Simon JC, Bailey MR. "Pulse focused ultrasound treatment of muscle mitigates paralysis-induced bone loss in the adjacent bone: a study in a mouse model." Ultrasound Med Biol. 2014 Sep;40(9):2113-24. Epub 2014 May 21. http://dx.doi.org/10.1016/j.ultrasmedbio.2014.02.027<\/a> ; PubMed PMID: 24857416; PubMed Central PMCID: PMC4410740, Sep-2014<\/p>", "files": "", "id": 46375, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Poliachik SL, Khokhlova TD, Wang YN, Simon JC, Bailey MR. "Pulse focused ultrasound treatment of muscle mitigates paralysis-induced bone loss in the adjacent bone: a study in a mouse model." Ultrasound Med Biol. Published online May 23, 2014. In press. http://dx.doi.org/10.1016/j.ultrasmedbio.2014.02.027<\/a> ; PubMed PMID: 24857416 , May-2014<\/p>", "files": "", "id": 46376, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Janssen KM, Brand TC, Cunitz BW, Wang YN, Simon JC, Starr F, Liggitt HD, Thiel J, Sorensen MD, Harper JD, Bailey MR, Dunmire B. "Safety and effectiveness of a longer focal beam and burst duration in ultrasonic propulsion for repositioning urinary stones and fragments." Journal of Endourology. 2017 Aug;31(8):793-9. [2017 May 24. Epub ahead of print] https://doi.org/10.1089/end.2017.0167<\/a> ; PubMed PMID: 28537452, Aug-2017<\/p>", "files": "", "id": 46359, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Simon JC, Sapozhnikov OA, Khokhlova VA, Wang Y-N, Crum LA, Bailey MR. "Ultrasonic atomization: A mechanism of tissue fractionation." Proceedings of Meetings on Acoustics. 2013 Jun;19(1):075036. http://dx.doi.org/10.1121/1.4800304<\/a> , Jun-2013<\/p>", "files": "", "id": 46381, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Sorensen MD, Bailey MR, Hsi RS, Cunitz BW, Simon JC, Wang YN, Dunmire BL, Paun M, Starr F, Lu W, Evan AP, Harper JD. "Focused ultrasonic propulsion of kidney stones: review and update of preclinical technology." J Endourol. 2013 Oct;27(10):1183-6. Review. http://dx.doi.org/10.1089/end.2013.0315<\/a> ; PubMed PMID: 23883117; PubMed Central PMCID: PMC3787400, Oct-2013<\/p>", "files": "", "id": 46385, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Harper JD, Sorensen MD, Cunitz BW, Wang YN, Simon JC, Starr F, Paun M, Dunmire B, Liggitt HD, Evan AP, McAteer JA, Hsi RS, Bailey MR. "Focused ultrasound to expel calculi from the kidney: safety and efficacy of a clinical prototype device." J Urol. 2013 Sep;190(3):1090-5. Epub 2013 Apr 9. http://dx.doi.org/10.1016/j.juro.2013.03.120<\/a> ; PubMed PMID: 23583535 ; PubMed Central PMCID: PMC4414252, Sep-2013<\/p>", "files": "", "id": 46356, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Khokhlova VA, Yuldashev PV, Rosnitskiy PB, Maxwell AD, Kreider W, Bailey MR, Sapozhnikov OA. "Design of HIFU transducers to generate specific nonlinear ultrasound fields." Physics Procedia. 2016;87:132-8. (45th Annual Symposium of the Ultrasonic Industry Association, UIA 45th Symposium, 4-6 April 2016, Seattle, WA, USA) https://doi.org/10.1016/j.phpro.2016.12.020<\/a> , Dec-2016<\/p>", "files": "", "id": 46363, "title": "Articles in Peer-reviewed Journals", "type": "Story" }, { "publishedBy": "", "description": "

Lingeman J. "American Urological Association Distinguished Contribution Award, February 2017." Feb-2017<\/p>", "files": "", "id": 46398, "title": "Awards", "type": "Story" }, { "publishedBy": "", "description": "

Hubbard M. "Mary Gates Undergraduate Research Scholarship, May 2015." May-2015<\/p>", "files": "", "id": 46397, "title": "Awards", "type": "Story" }, { "publishedBy": "", "description": "

Cunitz B. "Engineering and Urology Society Best Abstract award, May 2016." May-2016<\/p>", "files": "", "id": 46395, "title": "Awards", "type": "Story" }, { "publishedBy": "", "description": "

Crum L. "Acoustical Society of America Gold Medal, June 2013." Jun-2013<\/p>", "files": "", "id": 46391, "title": "Awards", "type": "Story" }, { "publishedBy": "", "description": "

Bruce M. "Best Poster. The 21st European Symposium on Ultrasound Contrast Imaging, June 2016. " Jun-2016<\/p>", "files": "", "id": 46390, "title": "Awards", "type": "Story" }, { "publishedBy": "", "description": "

Bailey M. "Promotion to Assoc. Prof., University of Washington, July 2016." Jul-2016<\/p>", "files": "", "id": 46389, "title": "Awards", "type": "Story" }, { "publishedBy": "", "description": "

Crum L. "Senior Visiting Fellow. Magdalen College, University of Oxford, January 2015." Jan-2015<\/p>", "files": "", "id": 46392, "title": "Awards", "type": "Story" }, { "publishedBy": "", "description": "

Crum L. "The William and Francis Fry Honorary Fellowship for Contributions to Therapeutic Ultrasound, April 2014." Apr-2014<\/p>", "files": "", "id": 46393, "title": "Awards", "type": "Story" }, { "publishedBy": "", "description": "

Cunitz B, Dunmire B, Paun M, Starr F, Wang Y. "University of Washington Distinguished Staff Award, April 2014." Apr-2014<\/p>", "files": "", "id": 46394, "title": "Awards", "type": "Story" }, { "publishedBy": "", "description": "

Harper J. "Promotion to Assoc. Prof., University of Washington, July 2016." Jul-2016<\/p>", "files": "", "id": 46396, "title": "Awards", "type": "Story" }, { "publishedBy": "", "description": "

Simon J. "Second Prize, NSBRI Dr. David Watson Poster Contest at the NASA Human Research Program Investigators' Workshop, January 2015." Jan-2015<\/p>", "files": "", "id": 46405, "title": "Awards", "type": "Story" }, { "publishedBy": "", "description": "

Simon J. "Promotion to Assist. Prof., January 2017." Jan-2017<\/p>", "files": "", "id": 46404, "title": "Awards", "type": "Story" }, { "publishedBy": "", "description": "

Simon J. "NSBRI Fellowship, February 2014." Feb-2014<\/p>", "files": "", "id": 46403, "title": "Awards", "type": "Story" }, { "publishedBy": "", "description": "

Schade, Khokhlova, Kreider, Bailey. "Best Paper. Engineering and Urology Society meeting at the American Urological Association annual meeting, May 2015." May-2015<\/p>", "files": "", "id": 46402, "title": "Awards", "type": "Story" }, { "publishedBy": "", "description": "

Purington B. "University of Washington Distinguished Staff Award, July 2016." Jul-2016<\/p>", "files": "", "id": 46401, "title": "Awards", "type": "Story" }, { "publishedBy": "", "description": "

McClenny A. "Mary Gates Undergraduate Research Scholarship, May 2015." May-2015<\/p>", "files": "", "id": 46400, "title": "Awards", "type": "Story" }, { "publishedBy": "", "description": "

Maxwell A. "Promotion to Research Assist. Prof., March 2017." Mar-2017<\/p>", "files": "", "id": 46399, "title": "Awards", "type": "Story" }, { "publishedBy": "", "description": "

Bailey M. "Elected to Acoustical Society of America Executive Council, April 2014." Apr-2014<\/p>", "files": "", "id": 46388, "title": "Awards", "type": "Story" }, { "publishedBy": "", "description": "

Lingeman JE, Beiko D, Bailey MR, Gettman MT, Kohrmann KU, Liatskos E, Matlaga BR, Monga M, Tailly G, Timoney A. "Stone Technology: Shock Wave and Intracorporeal Lithotripsy." in "Stone Disease. A Joint SIU-ICUD International Consultation Glasgow, Scotland, October 12–15, 2014." Ed. J. Denstedt, J. de la Rosette. Montreal: Société Internationale d’Urologie (SIU), 2015. p. 179-278., Jan-2015<\/p>", "files": "", "id": 46407, "title": "Books/Book Chapters", "type": "Story" }, { "publishedBy": "", "description": "

Sapozhnikov OA. "High-intensity ultrasonic waves in fluids: Nonlinear propagation and effects." in "Power Ultrasonics. Applications of High-intensity Ultrasound." Ed. J.A. Gallego-Juarez, K.F. Graff. Cambridge : Elsevier, 2015. p. 9-35. Woodhead Publishing Series in Electronic and Optical Materials: Number 66. http://dx.doi.org/10.1016/B978-1-78242-028-6.00002-8<\/a> , Jan-2015<\/p>", "files": "", "id": 46408, "title": "Books/Book Chapters", "type": "Story" }, { "publishedBy": "", "description": "

Lingeman JE, Beiko D, Bailey MR, Gettman MT, Kohrmann KU, Liatsikos E, Matlaga BR, Monga M, Gailly G, Timoney A. "Stone technology: shock wave and intracorporeal lithotripsy." in "3rd International Consultation on Stone Disease." Societe Internationale Urologique (Paris), In press as of June 2015., Jun-2015<\/p>", "files": "", "id": 46406, "title": "Books/Book Chapters", "type": "Story" }, { "publishedBy": "", "description": "

Simon J. "The thresholds and mechanisms of injury by focused ultrasound." Dissertation, Bioengineering, University of Washington, December 2013., Dec-2013<\/p>", "files": "", "id": 46409, "title": "Dissertations and Theses", "type": "Story" }, { "publishedBy": "HRP", "files": {"file": { "size": 67081, "id": 26179, "url": "https://techport.nasa.gov/file/26179" }}, "id": 35202, "publishedDate": "Dec 2016", "title": "HEOMD HRP Success Story Flexible Ultrasound System", "type": "Document" }, { "publishedBy": "", "description": "

Bailey MR. "Draft plan to integrate kidney stone imaging and repositioning into the Flexible Ultrasound Ground Demonstration Unit." Submitted to William Thompson, FUS Integration Lead and NSBRI headquarters, September 2013., Sep-2013<\/p>", "files": "", "id": 46410, "title": "NASA Technical Documents", "type": "Story" }, { "publishedBy": "", "description": "

Nikolaeva AV, Sapozhnikov OA, Bailey MR. "Acoustic radiation force of a quasi-Gaussian beam on an elastic sphere in a fluid." 2016 IEEE International Ultrasonics Symposium, Tours, France, September 18-21, 2016. In: 2016 IEEE International Ultrasonics Symposium. http://dx.doi.org/10.1109/ULTSYM.2016.7728608<\/a> , Sep-2016<\/p>", "files": "", "id": 46411, "title": "Papers from Meeting Proceedings", "type": "Story" }, { "publishedBy": "", "description": "

Oweis GF, Dunmire BL, Cunitz BW, Bailey MR. "Non-Invasive Measurement of the Temperature Rise in Tissue Surrounding a Kidney Stone Subjected to Ultrasonic Propulsion." 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS), Milan, Italy, August 25-29, 2015. Proceedings of the 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS), MiCo - Milano Conference Center - Milan, Italy, August 25-29, 2015. In press as of June 2015., Jun-2015<\/p>", "files": "", "id": 46412, "title": "Papers from Meeting Proceedings", "type": "Story" }, { "publishedBy": "", "description": "

American Urological Association. "Newsletter references NIDDK article on 'Moving kidney stones with ultrasound.' referencing journal article in J Urol--Harper JD, Cunitz BW, Dunmire B, Lee FC, Sorensen MD, Hsi RS, Thiel J, Wessells H, Lingeman JE, and Bailey MR. First in human clinical trial of ultrasonic propulsion of kidney stones. J Urol 195: 956-964, 2016. " AUA newsletter Eureka June 2016., Jun-2016<\/p>", "files": "", "id": 46413, "title": "Significant Media Coverage", "type": "Story" }, { "publishedBy": "", "description": "

Focused Ultrasound Foundation. "News highlighting PI's research and new funding: 'Focused Ultrasound in Outer Space?' " Focused Ultrasound Foundation newsletter. July 21, 2016. http://us8.campaign-archive2.com/?u=09c0cdb2fbbdcb0745213c8c5&id=70219944eb&e=44188d89b9<\/a> , Jul-2016<\/p>", "files": "", "id": 46418, "title": "Significant Media Coverage", "type": "Story" }, { "publishedBy": "", "description": "

Enerson J. "TV report, King 5 evening news, about PI's research." Healthlink section, TV report, King 5 evening news, January 10 2014. , Jan-2014<\/p>", "files": "", "id": 46417, "title": "Significant Media Coverage", "type": "Story" }, { "publishedBy": "", "description": "

Collins M. (Martha Collins) "Results of first clinical test of feasibility of ultrasound to reposition kidney stones." American Urological Association. AUA Daily News, p. 21. May 2015. http://auanews.auanet.org/i/509763-aua-news-may-2015/26<\/a> , May-2015<\/p>", "files": "", "id": 46416, "title": "Significant Media Coverage", "type": "Story" }, { "publishedBy": "", "description": "

McGrane C. "Article about PI's research, 'NASA-funded UW researchers develop kidney-stone zapping technology.' " GeekWire July 4 2016. https://www.geekwire.com/2016/nasa-funded-uw-researchers-develop-kidney-stone-zapping-technology/<\/a> , Jul-2016<\/p>", "files": "", "id": 46424, "title": "Significant Media Coverage", "type": "Story" }, { "publishedBy": "", "description": "

Hickey H. "Article about Dr. Bailey's research: 'Trial to test using ultrasound to move kidney stones.' " University of Washington online article, January 10, 2014. http://www.washington.edu/news/2014/01/10/trial-to-test-using-ultrasound-to-move-kidney-stones/?utm_source=rss&utm_medium=rss&utm_campaign=trial-to-test-using-ultrasound-to-move-k<\/a> ; accessed 6/4/14., Jan-2014<\/p>", "files": "", "id": 46420, "title": "Significant Media Coverage", "type": "Story" }, { "publishedBy": "", "description": "

Lyndon B. Johnson Space Center. "Article 'Soft-Tissue Emulsification Using a Mechanism of Ultrasonic Atomization Inside Gas or Vapor Cavities.' about PI Michael Bailey's work." NASA Tech Briefs, July 2016. MSC-25191-1. http://www.techbriefs.com/component/content/article/ntb/tech-briefs/bio-medical/24976<\/a> , Jul-2016<\/p>", "files": "", "id": 46423, "title": "Significant Media Coverage", "type": "Story" }, { "publishedBy": "", "description": "

Krader CG. (Cheryl Guttman Krader) "Rolling stones with ultrasound: Novel non-invasive technique shows diagnostic and therapeutic potential." Urology Times 2014., Sep-2014<\/p>", "files": "", "id": 46422, "title": "Significant Media Coverage", "type": "Story" }, { "publishedBy": "", "description": "

Hsi R, Sorensen M. "Focused ultrasonic propulsion of kidney stones, 'Beyond the Abstract.' Online article expanding on previously published article, 'Focused Ultrasonic Propulsion of Kidney Stones: Review and update of preclinical technology.' Published J Endourol. 2013 Oct;27(10):1183-6. http://dx.doi.org/10.1089/end.2013.0315<\/a> ; PubMed PMID: 23883117 " UroToday \u2013 Beyond the Abstract, January 8, 2014., Jan-2014<\/p>", "files": "", "id": 46421, "title": "Significant Media Coverage", "type": "Story" }, { "publishedBy": "", "description": "

Yard DH. (Delicia Honen Yard) "Ultrasonic Propulsion of Stones: Interview with Jonathan Harper, MD." Renal and Urology News Expert Q+A 2014. http://www.renalandurologynews.com/expert-qa/ultrasonic-propulsion-of-kidney-stones-interview-with-jonathan-harper-md/article/346605/<\/a> , Jul-2014<\/p>", "files": "", "id": 46429, "title": "Significant Media Coverage", "type": "Story" }, { "publishedBy": "", "description": "

Sullivan C. "Online news article, 'UW testing kidney stone treatment that doesn't need a hospital visit.' Online article about Dr. Bailey's research. " MYNorthwest.com January 14, 2014 @ 6:26 am (Updated: 11:03 am - 1/14/14) http://mynorthwest.com/11/2432495/UW-testing-kidney-stone-treatment-that-doesnt-need-a-hospital-visit<\/a> ; accessed 6/4/14., Jan-2014<\/p>", "files": "", "id": 46426, "title": "Significant Media Coverage", "type": "Story" }, { "publishedBy": "", "description": "

Wessells H. " 'Rolling Stones' article on Dr. Bailey's research." UW Urology Newsletter 2013., Jul-2013<\/p>", "files": "", "id": 46427, "title": "Significant Media Coverage", "type": "Story" }, { "publishedBy": "", "description": "

NIH National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) research update. " 'Moving stones with sound\u2014new ultrasound technology repositions kidney stones in people.' Article about PI's research and journal article in J Urol--Harper JD, Cunitz BW, Dunmire B, Lee FC, Sorensen MD, Hsi RS, Thiel J, Wessells H, Lingeman JE, and Bailey MR. First in human clinical trial of ultrasonic propulsion of kidney stones. J Urol 195: 956-964, 2016. " NIH NIDDK newsletter Jun 10 2016. https://www.niddk.nih.gov/news/research-updates/Pages/moving-stones-sound-new-ultrasound-technology-repositions-kidney-stones-people.aspx<\/a> , Jun-2016<\/p>", "files": "", "id": 46425, "title": "Significant Media Coverage", "type": "Story" }, { "publishedBy": "", "description": "

Bailey MR. "Dissolving Kidney Stones With Ultrasound." AIUM (American Institute of Ultrasound in Medicine) Soundwaves July 13, 2016, http://www.aium.org<\/a> , Jul-2016<\/p>", "files": "", "id": 46415, "title": "Significant Media Coverage", "type": "Story" }, { "publishedBy": "", "description": "

Fulwiler D. "Online article about Dr. Bailey's research, 'Former ITHS Grant Awardee's Ultrasound Device Begins Clinical Trials.' " Institute of Translational Health Sciences online article, January 2014., Jan-2014<\/p>", "files": "", "id": 46419, "title": "Significant Media Coverage", "type": "Story" }, { "publishedBy": "", "description": "

Yard DH. (Delicia Honen Yard) "Expert Q&A." Renal & Urology News Q and A series. May 2014. http://www.renalandurologynews.com/expert-qa/section/2304/<\/a> ; accessed 6/4/14., May-2014<\/p>", "files": "", "id": 46428, "title": "Significant Media Coverage", "type": "Story" }, { "publishedBy": "", "description": "

AUA Daily News Editor. "Article about Dr. Bailey's research, 'New Device uses ultrasonic propulsion to move stones in the kidney.' " TriStar AUA Daily News, May 7, 2013, p. 13., May-2013<\/p>", "files": "", "id": 46414, "title": "Significant Media Coverage", "type": "Story" } ]}, "technologyMaturityStart": 4, "responsibleMissionDirectorateOrOffice": "Human Exploration and Operations Mission Directorate", "id": 18872, "startDate": "Jun 2013", "status": "Completed" }}